Comparative efficacy and safety of anticoagulants and aspirin for extended treatment of venous thromboembolism: A network meta-analysis

Thrombosis Research
Diana M SobierajAdrian V Hernandez

Abstract

To systematically review the literature and to quantitatively evaluate the efficacy and safety of extended pharmacologic treatment of venous thromboembolism (VTE) through network meta-analysis (NMA). A systematic literature search (MEDLINE, Embase, Cochrane CENTRAL, through September 2014) and searching of reference lists of included studies and relevant reviews was conducted to identify randomized controlled trials of patients who completed initial anticoagulant treatment for VTE and then randomized for the extension study; compared extension of anticoagulant treatment to placebo or active control; and reported at least one outcome of interest (VTE or a composite of major bleeding or clinically relevant non-major bleeding). A random-effects Frequentist approach to NMA was used to calculate relative risks with 95% confidence intervals. Ten trials (n=11,079) were included. Risk of bias (assessed with the Cochrane tool) was low in most domains assessed across the included trials. Apixaban (2.5mg and 5mg), dabigatran, rivaroxaban, idraparinux and vitamin K antagonists (VKA) each significantly reduced the risk of VTE recurrence compared to placebo, ranging from a 73% reduction with idraparinux to 86% with VKAs. With exception of id...Continue Reading

References

Jul 21, 2001·The New England Journal of Medicine·G AgnelliUNKNOWN Warfarin Optimal Duration Italian Trial Investigators
Jul 2, 2003·Annals of Internal Medicine·Giancarlo AgnelliUNKNOWN Warfarin Optimal Duration Italian Trial Investigators
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Sep 15, 2007·The New England Journal of Medicine·UNKNOWN van Gogh InvestigatorsGary E Raskob
Jun 15, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·David C HoaglinAnnabel Barrett
Nov 6, 2012·The New England Journal of Medicine·Timothy A BrightonUNKNOWN ASPIRE Investigators
Feb 22, 2013·The New England Journal of Medicine·Sam SchulmanUNKNOWN RE-SONATE Trial Investigators
Mar 19, 2013·BMC Medical Research Methodology·Ulrike KrahnJochem König
Mar 27, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·UNKNOWN Cardiovascular Disease Educational and Research TrustUNKNOWN Union Internationale du Phlebologie
May 16, 2013·BMJ : British Medical Journal·Edward J MillsJohn P A Ioannidis

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Citations

Nov 8, 2016·Journal des maladies vasculaires·J-P Laroche, J-F Schved
May 31, 2017·Critical Care Nursing Quarterly·Adebayo FasanyaKhalid Malik
Jun 7, 2020·Archives of Orthopaedic and Trauma Surgery·Jessica H HeyerAndrew S Neviaser
Oct 4, 2019·International Angiology : a Journal of the International Union of Angiology·Kurt G SeagraveKerry Hitos
Oct 19, 2020·International Journal of Clinical Pharmacy·Syed Shahzad HasanSyed Tabish Razi Zaidi
Jun 16, 2021·Seminars in Thrombosis and Hemostasis·Mikael ChristiansenAnne-Mette Hvas

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