Abstract
This was a 4-week, three-center, double-blind, randomized, parallel, placebo-controlled evaluation of the efficacy and safety of bupropion in hospitalized depressed patients. Results from 27 placebo and 48 bupropion-treated patients were analyzed for efficacy and safety. Assessments of efficacy and safety were made at baseline and weekly during the study. Preliminary and secondary measures of efficacy included the Clinical Global Impressions for severity (CGI-S) and improvement (CGI-I) of illness, Hamilton Depression and Hamilton Anxiety Scales, and the Zung Self-Rating Scales for depression and anxiety. Assessments of safety included vital signs, electrocardiogram, clinical laboratory tests, and adverse experiences. Dosages of bupropion were 300-600 mg/day. Results showed that bupropion was significantly (P less than 0.01) more effective than placebo at termination of study on the CGI-S, CGI-I, Hamilton Depression and Hamilton Anxiety Scales. On the Zung Self-Rating Depression and Anxiety Scales, statistical trends favored bupropion at termination of study over placebo (P less than 0.10). Adverse events in the bupropion and placebo groups were minimal with notable absence of sedation and anticholinergic- and cardiovascular-rel...Continue Reading
References
Dec 1, 1977·The Journal of Pharmacy and Pharmacology·F E SorokoD H Schroeder
Nov 12, 1979·Life Sciences·W C SternH Meltzer
Nov 1, 1973·Psychosomatics·W W Zung
Nov 1, 1971·Psychosomatics·W W Zung
Nov 1, 1971·Psychosomatics·W W Zung
Oct 1, 1983·Paraplegia·J J WyndaeleH Claessens
Jan 1, 1959·The British Journal of Medical Psychology·M HAMILTON
Jan 1, 1965·Archives of General Psychiatry·W W ZUNG
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Citations
Jan 1, 1983·Psychopharmacology·L Miller, J Griffith
Jul 1, 1983·Neuropharmacology·O GandolfiE Costa
Apr 1, 1986·Pharmacology, Biochemistry, and Behavior·J A NielsenK E Moore
May 20, 1999·Journal of Affective Disorders·W D Horst, S H Preskorn
Jul 15, 1998·Clinical Therapeutics·F W ReimherrJ A Ascher
Nov 12, 2005·Substance Use & Misuse·Kathleen T Brady, Marcia L Verduin
Apr 4, 2015·Drug Delivery·Jaleh VarshosazHossein Jaleh
Jun 16, 2010·Journal of Pharmaceutical and Biomedical Analysis·Paul M O'ByrneJohn F Gilmer
May 27, 2008·Psychiatry Research·Ixchel Herrera-GuzmánJoan Guardia-Olmos
Jan 1, 1985·Acta Psychiatrica Scandinavica. Supplementum·D CostaT Toma
Jun 20, 2015·BioMed Research International·Jaleh VarshosazJaafar Banoozadeh
Jul 28, 2006·Journal of Psychiatric Research·Charles B Nemeroff
Jan 17, 2002·The Annals of Pharmacotherapy·C E Nieuwstraten, L R Dolovich
Nov 25, 2003·The Annals of Pharmacotherapy·Pieter StolkThomas R Einarson
Oct 20, 2006·Journal of Psychopharmacology·David NuttSteven Stahl
Feb 6, 2010·Psychiatry and Clinical Neurosciences·Hyungin ChoiKenji Fukui
Oct 26, 1999·The British Journal of Psychiatry : the Journal of Mental Science·P BolliniC Munizza
Sep 25, 2012·The Journal of Urology·Yasuyuki NaitohTsuneharu Miki
Jan 1, 1989·Psychological Medicine. Monograph Supplement·S J WarringtonM Lader