Comparative efficacy and safety of interventions for preventing chemotherapy-induced oral mucositis in adult cancer patients: a systematic review and network meta-analysis.

European Journal of Hospital Pharmacy. Science and Practice
Preyanate WilairatSurasak Saokaew

Abstract

To examine the comparative efficacy and safety of interventions for preventing chemotherapy-induced oral mucositis (OM) in adult cancer patients. We searched PubMed, Embase and the Cochrane Central systematically for the randomised control trials (RCTs) of interventions for preventing OM. Network meta-analysis (NMA) was performed to estimate risk ratios (RR) and 95% confidence intervals (CI) from both direct and indirect evidence. The primary outcome was any grade of OM. Secondary outcomes were mild-moderate OM, severe OM and adverse events, such as taste disturbance and gastrointestinal adverse events. This study was registered with PROSPERO, number CRD42016052489. A total of 29 RCTs with 2348 patients (median age, 56.1 years; 57.5% male) were included. Cryotherapy was associated with a significantly lower risk of OM than control (RR 0.51, 95% CI 0.38 to 0.68), and zinc sulphate (RR 0.47, 95% CI 0.23 to 0.97), but not significantly lower than sucralfate and palifermin. No significant differences were observed between cryotherapy and control for taste disturbance and gastrointestinal adverse events. Palifermin was associated with the highest risk of taste disturbance. This NMA suggests that cryotherapy was the most effective in...Continue Reading

References

Mar 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D J MahoodN L Gusa
Mar 1, 1990·Oral Surgery, Oral Medicine, and Oral Pathology·G A FerrettiR C Ash
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Sep 1, 1985·Oral Surgery, Oral Medicine, and Oral Pathology·W T McGaw, A Belch
Jul 1, 1994·European Journal of Cancer. Part B, Oral Oncology·S CascinuG Catalano
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Sep 5, 2002·Statistics in Medicine·Thomas Lumley
Jan 16, 2003·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Michelle NottageMalcolm J Moore
Apr 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Neal J MeropolLee S Rosen
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Jan 17, 2004·Seminars in Oncology·Don A GabrielTerrance Comeau
Apr 27, 2004·Cancer·Stephen T SonisUNKNOWN International Society for Oral Oncology
Sep 28, 2004·Statistics in Medicine·G Lu, A E Ades
Jun 11, 2005·Journal of Clinical Nursing·Serife Karagözoğlu, Mehlika Filiz Ulusoy
Apr 8, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jeffrey A JonesLinda S Elting
Jul 11, 2006·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·E PapadeasCh Kalofonos
Sep 5, 2006·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Kwon ChoiJeong Wook Kim
Nov 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lee S RosenStephen Clarke
Dec 2, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Montserrat Vera-LlonchStephen Sonis
Jun 21, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Linda S EltingChristos Emmanoulides
Mar 10, 2010·Statistics in Medicine·S DiasA E Ades
Jan 5, 2011·Journal of Clinical Epidemiology·Gordon GuyattHolger J Schünemann
Apr 15, 2011·The Cochrane Database of Systematic Reviews·Helen V WorthingtonTasneem Khalid
Sep 14, 2011·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Nilgün KatrancıAlper Sevinc
Oct 20, 2011·BMJ : British Medical Journal·Julian P T HigginsUNKNOWN Cochrane Statistical Methods Group
Jul 1, 2010·National Journal of Maxillofacial Surgery·Afshan BeySarwat H Hashmi
Jan 16, 2013·Chemotherapy Research and Practice·Katrin Sak
Mar 20, 2013·International Journal of Epidemiology·Areti Angeliki VeronikiGeorgia Salanti
Oct 8, 2013·PloS One·Anna ChaimaniGeorgia Salanti
Mar 13, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ajay K NookaEdmund K Waller
Mar 13, 2014·Cancer·Rajesh V LallaUNKNOWN Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer and International Societ
Aug 22, 2014·British Journal of Haematology·Kenneth F BradstockUNKNOWN Australasian Leukaemia and Lymphoma Group
Sep 26, 2014·BMJ : British Medical Journal·Milo A PuhanUNKNOWN GRADE Working Group
Oct 28, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Andreza BarkokebasJair Carneiro Leão

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Citations

Oct 22, 2020·Revista latino-americana de enfermagem·Andrea Bezerra RodriguesThays Silva De Souza Lopes
Jun 2, 2021·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·Mattia BerroneGiovanni Succo
Jun 29, 2021·Current Physical Medicine and Rehabilitation Reports·Jasmine Y ZhengMitra D McLarney

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