PMID: 9555822Apr 29, 1998Paper

Comparative efficacy and safety of two 0.025% tretinoin gels: results from a multicenter double-blind, parallel study

Journal of the American Academy of Dermatology
A W LuckyJ W Quigley

Abstract

The addition of polyolprepolymer-2 in tretinoin formulations may reduce tretinoin-induced cutaneous irritation. This study compared the efficacy and safety of a new 0.025% tretinoin gel containing polyolprepolymer-2, its vehicle, and a commercially-available 0.025% tretinoin gel in patients with mild to moderate acne vulgaris. In this 12-week multicenter, double-blind, parallel group study, efficacy was evaluated by objective lesion counts and the investigators' global evaluations. Subjective assessment of cutaneous irritation by the investigators and patients evaluated safety. The efficacy of the two active treatments in this 215 patient study was comparable, and both treatments were statistically significantly more effective than vehicle. When compared with the commercially-available tretinoin gel, the formulation containing polyolprepolymer-2 demonstrated statistically significantly less peeling at days 28, 56, and 84, statistically significantly less dryness by day 84, and statistically significantly less itching at day 14. Irritation scores for the formulation containing polyolprepolymer-2 were numerically lower but not statistically different from those of the commercially-available gel for erythema and burning. The numbe...Continue Reading

References

Jul 1, 1986·Archives of Dermatology·L M Milstone
Apr 1, 1969·Archives of Dermatology·A M KligmanG Plewig

❮ Previous
Next ❯

Citations

Mar 4, 2000·Clinics in Dermatology·A Arechalde, J H Saurat
Feb 15, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·J E Wolf
May 10, 2011·Journal of the American Academy of Dermatology·Stanley ShapiroStephan Lanes
Feb 6, 2007·Journal of the American Academy of Dermatology·John S StraussUNKNOWN American Academy of Dermatology/American Academy of Dermatology Association
May 16, 2008·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Anja ThielitzHarald Gollnick
Nov 24, 2004·Clinics in Dermatology·Andrea Krautheim, Harald P M Gollnick
Jan 8, 2000·Dermatologic Clinics·D M Thiboutot
Mar 31, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·A NastUNKNOWN European Dermatology Forum
Oct 12, 2001·Seminars in Cutaneous Medicine and Surgery·S Bershad
Jul 2, 2003·Journal of the American Academy of Dermatology·Harald GollnickUNKNOWN Global Alliance to Improve Outcomes in Acne
Apr 29, 1998·Journal of the American Academy of Dermatology·J J Leyden
Oct 4, 2018·The New England Journal of Medicine·Andrea L Zaenglein
Feb 23, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·B DrénoC Carré
Feb 23, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·A D Katsambas
Nov 1, 2008·American Journal of Clinical Dermatology·Anja Thielitz, Harald Gollnick
Jun 20, 2003·American Journal of Clinical Dermatology·Arash Akhavan, Susan Bershad
May 14, 2011·Postgraduate Medicine·Peter HsuRobert T Brodell
Jun 21, 2007·Journal of Microencapsulation·Gisele A CastroLucas A M Ferreira
Mar 23, 2000·Postgraduate Medicine·B A Johnson, J R Nunley
Apr 20, 2021·American Journal of Clinical Dermatology·Hilary BaldwinEric Guenin
Sep 5, 2006·Pediatrics·Andrea L Zaenglein, Diane M Thiboutot

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.