Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis

Lancet
Stefan LeuchtJohn M Davis

Abstract

The question of which antipsychotic drug should be preferred for the treatment of schizophrenia is controversial, and conventional pairwise meta-analyses cannot provide a hierarchy based on the randomised evidence. We aimed to integrate the available evidence to create hierarchies of the comparative efficacy, risk of all-cause discontinuation, and major side-effects of antipsychotic drugs. We did a Bayesian-framework, multiple-treatments meta-analysis (which uses both direct and indirect comparisons) of randomised controlled trials to compare 15 antipsychotic drugs and placebo in the acute treatment of schizophrenia. We searched the Cochrane Schizophrenia Group's specialised register, Medline, Embase, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov for reports published up to Sept 1, 2012. Search results were supplemented by reports from the US Food and Drug Administration website and by data requested from pharmaceutical companies. Blinded, randomised controlled trials of patients with schizophrenia or related disorders were eligible. We excluded trials done in patients with predominant negative symptoms, concomitant medical illness, or treatment resistance, and those done in stable patients. Data fo...Continue Reading

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Jan 21, 2018·European Archives of Psychiatry and Clinical Neuroscience·Johann SteinerHans-Gert Bernstein
Jan 12, 2019·Journal of Psychiatric Practice·Ronnie SolomonAbed N Azab
Jan 25, 2019·Journal of Psychopharmacology·Rafal A H YeisenStein Opjordsmoen
Jan 25, 2019·Journal of Child and Adolescent Psychopharmacology·Lenneke MinjonEibert R Heerdink
Mar 7, 2018·Journal of Psychiatric Practice·Temilola SalamiPhuong T Nguyen
Feb 2, 2018·BMC Complementary and Alternative Medicine·Kai-Huan WangMeng-Wei Ni
Feb 2, 2019·The Annals of Pharmacotherapy·Sue LeeLaura Baumgartner
Jan 24, 2019·Drugs·James E Frampton
Feb 1, 2019·Expert Review of Clinical Pharmacology·Giuseppe CicalaJose de Leon
Mar 9, 2019·International Journal of Psychiatry in Clinical Practice·José María Bonete LlácerBegoña Richart Albelda
Mar 16, 2019·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Gareth HopkinHuseyin Naci
Mar 21, 2019·The New England Journal of Medicine·Justin A ChenScott R Beach
Apr 17, 2019·The Cochrane Database of Systematic Reviews·Julie Broderick, Davy Vancampfort
Nov 6, 2018·Current Drug Targets·Surovi SaikiaRajeev Sarmah
Oct 31, 2017·Journal of Market Access & Health Policy·Clément FrançoisMondher Toumi
May 7, 2019·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Taishiro KishimotoChristoph U Correll
Mar 25, 2019·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Jeong Ha ParkDoug Hyun Han
Mar 25, 2019·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Gavin P ReynoldsMichael K Harte
Feb 21, 2019·Annual Review of Clinical Psychology·Joel T Braslow, Stephen R Marder
Mar 31, 2019·British Journal of Clinical Pharmacology·Mikkel HøjlundChristoph U Correll
Jan 1, 2015·Nature Reviews. Disease Primers·Rene KahnThomas R Insel
May 28, 2019·Expert Opinion on Pharmacotherapy·Donatella MarazzitiLiliana Dell'Osso
May 30, 2019·Nordic Journal of Psychiatry·Renata AlisauskieneErik Johnsen
Jul 18, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Philipp HomanAnil Malhotra
Jul 26, 2019·Molecular Genetics & Genomic Medicine·Dafei ZhanChuanlong Yu
Nov 27, 2014·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Taro KishiNakao Iwata
Jul 12, 2019·Journal of Psychopharmacology·Jacobi I CunninghamMark Namchuk
Aug 25, 2019·European Archives of Psychiatry and Clinical Neuroscience·Katrin DruschkySusanne Stübner
Jan 1, 2016·Journal of Neurophysiology·Imran J AnwarAndrea Zsombok
Jul 16, 2017·Journal of Basic and Clinical Physiology and Pharmacology·Patrick AmoatengAlexander K Nyarko
Jun 4, 2019·The Cochrane Database of Systematic Reviews·Yusuke OgawaToshi A Furukawa
Sep 15, 2019·Basic & Clinical Pharmacology & Toxicology·Dora KollerFrancisco Abad-Santos
Aug 9, 2017·BMC Complementary and Alternative Medicine·Patrick AmoatengSamuel B Kombian
Apr 3, 2018·Therapeutic Advances in Psychopharmacology·Ian J OsborneD Taylor
Oct 1, 2019·Expert Opinion on Drug Safety·Wade MarteeneD Siskind
Mar 8, 2018·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Jeffrey P ReissKamini Vasudev
Sep 6, 2019·Human Psychopharmacology·Konstantinos N FountoulakisIoannis Nimatoudis
Oct 31, 2019·The New England Journal of Medicine·Stephen R Marder, Tyrone D Cannon
Aug 14, 2018·Current Neuropharmacology·Antonio Del CasaleMaurizio Pompili
Nov 3, 2018·Current Clinical Pharmacology·Georgios Papazisis, Spyridon Siafis
Nov 26, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yuya MizunoOliver D Howes
Jun 4, 2019·The American Journal of Psychiatry·Ned H Kalin
Jan 16, 2020·European Journal of Clinical Pharmacology·Arto PuranenHeidi Taipale
Dec 7, 2017·Journal of Clinical Psychopharmacology·Lindsay-Rose Dykema
Oct 31, 2019·JAMA Psychiatry·Robert McCutcheonOliver D Howes
Dec 17, 2019·The American Journal of Psychiatry·Stefan LeuchtJohn M Davis
Dec 1, 2017·Neurology. Clinical Practice·Davide Martino, Francesca Morgante
Jun 27, 2017·Journal of Clinical Psychopharmacology·Roisin DoyleMary Clarke
Jul 19, 2017·Journal of Clinical Psychopharmacology·Shuhua DengChang Qiu
Aug 9, 2017·Journal of Clinical Psychopharmacology·Anders JørgensenHenrik Berg Rasmussen
Jan 9, 2020·JAMA Psychiatry·Christoph U CorrellKimberly E Vanover
Feb 22, 2020·Metabolites·Elke HumerChristoph Pieh
Feb 25, 2020·British Journal of Clinical Pharmacology·Lin LiYu-Ping Ning
Feb 19, 2020·Journal of Clinical Psychopharmacology·Fabian Wagner, Armin Kalenka
Feb 21, 2020·Journal of Periodontology·I-Ching WangHom-Lay Wang
Jan 19, 2020·Expert Opinion on Drug Safety·Barbara B BartonRichard Musil
Dec 14, 2019·Journal of Clinical Psychopharmacology·Takuro SugaiToshiyuki Someya
Oct 28, 2019·Journal of General Internal Medicine·Praveen IndraratnaBen Ng
Apr 14, 2020·Early Intervention in Psychiatry·Nikola NikolićRichard Whale
Apr 16, 2020·The New England Journal of Medicine·Kenneth S KoblanAntony Loebel
Mar 20, 2020·Expert Opinion on Drug Safety·Juan Carlos Ruiz DiazWilbert S Aronow
Apr 16, 2020·Expert Review of Pharmacoeconomics & Outcomes Research·Zhan-Miao YiSuodi Zhai