PMID: 9444446Jan 28, 1998Paper

Comparative efficacy and tolerability of two long-acting calcium antagonists, mibefradil and amlodipine, in essential hypertension. Mibefradil Hypertension Study Group

Clinical Therapeutics
F E KarchJ N Tarro

Abstract

In a previous forced-titration trial, mibefradil 100 mg QD was as effective as amlodipine 10 mg QD in reducing sitting diastolic blood pressure (SDBP), and it produced significantly less leg edema than did amlodipine 10 mg QD. The present multicenter, double-masked, randomized, parallel-design trial was performed to assess the reproducibility of these results using a flexible-titration design. Following a 4-week, single-masked, placebo run-in period, 296 patients with a trough SDBP of between 95 and 114 mm Hg (21 to 27 hours postdose) were randomized to receive once-daily treatment with mibefradil 50 mg (n = 146) or amlodipine 5 mg (n = 150). In patients whose trough SDBP was greater than 90 mm Hg after 4 or 8 weeks of double-masked therapy, the dosage was titrated upward to mibefradil 100 mg or amlodipine 10 mg for the remainder of the 12-week active treatment period. A greater proportion of amlodipine-treated patients (65%) than of mibefradil-treated patients (54%) required titration to the higher dose. Despite this difference, statistically equivalent reductions in trough SDBP were observed after 12 weeks of treatment with 50 to 100 mg of mibefradil QD (-11.7 +/- 6.4 mm Hg) and 5 to 10 mg of amlodipine QD (-11.9 +/- 6.9 mm H...Continue Reading

References

Nov 1, 1991·Archives of Internal Medicine·W ZingP H Vlasses
Jan 1, 1988·Journal of Cardiovascular Pharmacology·W J MroczekK S Allenby
Oct 24, 1986·JAMA : the Journal of the American Medical Association·L X CubedduT Eades
Jun 1, 1987·American Heart Journal·W B KannelL A Cupples
Jan 1, 1984·Journal of Cardiovascular Pharmacology·M MoserN D Vlachakis
Sep 1, 1984·American Heart Journal·R S HornungE B Raftery
Oct 1, 1982·American Heart Journal·R F Gillum, C T Grant
Jul 4, 1995·European Journal of Pharmacology·A Rutledge, D J Triggle
Jul 1, 1994·Circulation Research·S K Mishra, K Hermsmeyer

❮ Previous
Next ❯

Citations

Feb 5, 2013·North American Journal of Medical Sciences·Ranjan ShettyK L Bairy
Mar 15, 2003·Clinical Therapeutics·Cindy B LevineVeronica Ludensky
Jan 7, 2006·Biometrical Journal. Biometrische Zeitschrift·S Lange, G Freitag

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.