PMID: 7547726May 1, 1995Paper

Comparative efficacy of nonsteroidal anti-inflammatory drugs and anti-thromboxane agents in a rabbit adhesion-prevention model

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
E K LeGrandG S diZerega

Abstract

A variety of nonsteroidal anti-inflammatory drugs (NSAIDs) has been found to inhibit postsurgical peritoneal adhesion formation in a number of animal models. A rabbit uterine horn adhesion model was used to directly compare several commonly used NSAIDs of different chemical classes in a single animal study to evaluate their ability to prevent adhesion formation. The effect of thromboxane inhibitors on adhesion prevention was also evaluated. Each of the NSAIDs tested (tolmetin, ibuprofen, aspirin, and indomethacin) showed significant and comparable efficacy. In this same study, imidazole, a thromboxane synthetase inhibitor, also showed significant efficacy. In a second study, ridogrel, an inhibitor of thromboxane synthetase as well as a thromboxane A2 receptor blocker, also showed significant efficacy in reducing peritoneal adhesion severity. These results further support the view that NSAIDs act to prevent adhesions through a common mechanism. In addition, thromboxane A2 inhibitors were also shown to be efficacious in adhesion prevention, suggesting that platelets may play a substantial role in adhesion formation.

References

Apr 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·P NeedlemanM Minkes
Oct 1, 1992·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·G BazzoniA Del Maschio
Oct 1, 1992·Journal of Comparative Pathology·P A Gentry
Jan 1, 1992·The Journal of Surgical Research·R S WilliamsG Schultz
Dec 1, 1991·American Journal of Obstetrics and Gynecology·A SteinleitnerB Robin
Sep 3, 1991·The American Journal of Cardiology·G A FitzGerald
Jan 1, 1990·Tissue Antigens·J AwadG Fostizopoulos
Jan 1, 1990·The Journal of Burn Care & Rehabilitation·W B Rockwell, H P Ehrlich
Jan 1, 1989·Immunopharmacology·C P Page
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S M WahlM B Sporn
Dec 1, 1986·American Journal of Obstetrics and Gynecology·J C Jarrett, M Y Dawood
Apr 1, 1984·The Journal of Trauma·H P Ehrlich
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T F DeuelE T Kaiser
Apr 1, 1982·The Journal of Clinical Investigation·T F DeuelG L Griffin
Jan 1, 1994·The Journal of Surgical Research·E K LeGrandT C Kiorpes

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Citations

Apr 15, 2006·Digestive Diseases and Sciences·Amir Khorram-ManeshDick Delbro
Dec 29, 2009·The Journal of Surgical Research·Brian C Ward, Alyssa Panitch
Jul 22, 2008·Biomaterials·Sangamesh G KumbarCato T Laurencin
Jul 20, 2010·The Journal of Surgical Research·Johanne D CashmanChristopher M K Springate
Sep 27, 2008·International Journal of Surgery·Tarek MahdyAdel Elhawary
Sep 30, 2014·The Journal of Surgical Research·Simon T K YauwHarry van Goor
Sep 21, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Yoon Yeo, Daniel S Kohane
Feb 8, 2011·Fertility and Sterility·Roberta CoronaPhilippe Robert Koninckx
Jul 13, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kwangsok KimMichael Hadjiargyrou
May 8, 2003·The British Journal of Surgery·M M P J ReijnenH van Goor
Nov 25, 1998·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·K E RodgersG S diZerega
Sep 2, 2020·Acta Biomaterialia·Jingyi TangShengfu Chen

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