PMID: 16521631Mar 9, 2006Paper

Comparative efficacy of once daily parnaparin and unfractionated heparin in unstable angina pectoris: PRIME CARE study

Indian Heart Journal
PRIME CARE Study Investigators Group

Abstract

This study sought to compare the efficacy of low molecular weight heparin, parnaparin and unfractionated heparin in Indian patients presenting with unstable angina pectoris. In this randomized, prospective and multicentre trial 897 adult patients of both sexes suffering from unstable angina were included. All patients also received oral aspirin and adequate anti-anginal treatment as per their individual needs. Patients in unfractionated heparin group received unfractionated heparin as an intravenous bolus of 5000 IU followed by an intravenous infusion of 800 to 1000 IU/hour for 48 hours, followed by 5000 IU subcutaneously every 6 hours for 5 days. The patients in the other group were treated with parnaparin sodium 6400 IU subcutaneously once daily for 7 days. In the unfractionated heparin group there were 446 patients (310 males, 136 females) with a mean age of 55.9 + 12.27 years and in parnaparin group 451 patients (312 males, 139 females) with a mean age of 57.6 +/- 11.19 years. Both the groups were similar with respect to age and sex (p = 0.89 and 0.068, respectively). The associated cardiovascular risk factors such as diabetes, hypertension, dyslipidemia, previous myocardial infarction and previous coronary artery bypass gr...Continue Reading

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