Comparative efficacy of postoperative transarterial chemoembolization with or without antiviral therapy for hepatitis B virus-related hepatocellular carcinoma

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Shao-Liang ZhuLe-Qun Li

Abstract

This study aims to investigate the efficacy of adjuvant transarterial chemoembolization (TACE) with or without antiviral therapy for patients with hepatocellular carcinoma (HCC) after radical hepatectomy. This retrospective study examined 176 patients after radical hepatectomy, 118 of whom were treated using TACE alone and 58 using TACE combined with antiviral therapy. To reduce confounding bias due to baseline differences, propensity score matching was used to generate 51 pairs of patients from both treatment groups. Overall survival (OS) and disease-free survival (DFS) were analyzed for both groups before and after propensity score matching. Analysis of all patients showed that OS was better in the combination therapy group than in the TACE-only group (P = 0.048), while DFS was similar between the two groups (P = 0.322). Analysis of only propensity score-matched pairs confirmed the significantly better 5-year OS in the combination therapy group (64.6 vs. 37.5 %, P = 0.033) and also suggested better 5-year DFS (37.9 vs. 14.6 %, P = 0.048). Among patients experiencing HCC recurrence, radical surgery was the treatment choice for a significantly larger proportion of patients from the combination therapy group than from the TACE-o...Continue Reading

References

Feb 24, 2001·Journal of Gastroenterology and Hepatology·I MericanD Z Xu
Oct 8, 2004·The New England Journal of Medicine·Yun-Fan LiawUNKNOWN Cirrhosis Asian Lamivudine Multicentre Study Group
Oct 5, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Jian-Hong Zhong, Le-Qun Li
Jan 28, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J-H ZhongG-B Wu
Feb 14, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Xiang-Ming LaoYunfei Yuan
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Apr 11, 2014·Scandinavian Journal of Gastroenterology·Jian-Hong ZhongLe-Qun Li
Aug 15, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jian-Hong ZhongHang Li

❮ Previous
Next ❯

Citations

Sep 8, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Song-Lin MaJing-Hang Jiang
Oct 28, 2019·Expert Review of Gastroenterology & Hepatology·Shi-Dong LuJian-Hong Zhong
May 19, 2020·Antiviral Chemistry & Chemotherapy·Mohamed A Abd El AzizAntonio Facciorusso

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.