Comparative Efficacy of Therapies for Treatment of Depression for Patients Undergoing Maintenance Hemodialysis: A Randomized Clinical Trial

Annals of Internal Medicine
Rajnish MehrotraS Susan Hedayati

Abstract

Although depression is common among patients receiving maintenance hemodialysis, data on their acceptance of treatment and on the comparative efficacy of various therapies are limited. To determine the effect of an engagement interview on treatment acceptance (phase 1) and to compare the efficacy of cognitive behavioral therapy (CBT) versus sertraline (phase 2) for treating depression in patients receiving hemodialysis. Multicenter, parallel-group, open-label, randomized controlled trial. (ClinicalTrials.gov: NCT02358343). 41 dialysis facilities in 3 U.S. metropolitan areas. Patients who had been receiving hemodialysis for at least 3 months and had a Beck Depression Inventory-II score of 15 or greater; 184 patients participated in phase 1, and 120 subsequently participated in phase 2. Engagement interview versus control visit (phase 1) and 12 weeks of CBT delivered in the dialysis facility versus sertraline treatment (phase 2). The primary outcome for phase 1 was the proportion of participants who started depression treatment within 28 days. For phase 2, the primary outcome was depressive symptoms measured by the Quick Inventory of Depressive Symptoms-Clinician-Rated (QIDS-C) at 12 weeks. The proportion of participants who init...Continue Reading

Associated Clinical Trials

References

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Citations

Jun 5, 2019·Journal of the American Society of Nephrology : JASN·Joseph Chilcot, Ken Farrington
Feb 14, 2020·Journal of Renal Care·Ayman GuirguisKen Farrington
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May 6, 2021·The Journal of Nutrition, Health & Aging·N KuritaY Ishibashi
Aug 31, 2021·Current Opinion in Nephrology and Hypertension·Na TianPhilip Kam-Tao Li

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Methods Mentioned

BETA
Cognitive Behavioral Therapy

Clinical Trials Mentioned

NCT02358343

Software Mentioned

R
Stata IC

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