PMID: 28989Jan 1, 1978

Comparative efficacy of triazolam, flurazepam and placebo in out-patients insomniacs

The Journal of International Medical Research
A J Bowen

Abstract

The short-term hypnotic efficacy of triazolam was compared to that of flurazepam and placebo in 120 out-patient insomniacs. Each patient was studied with a two-night, double-blind crossover trial. Triazolam (0.5 mg) was compared to placebo and flurazepam (30 mg). Triazolam (0.25 mg) was compared to flurazepam (15 mg and 30 mg). Triazolam (0.5 mg) was preferred to both placebo and flurazepam (30 mg). Triazolam (0.5 mg) was superior to placebo in improving quality of sleep, shortening sleep onset, increasing sleep duration, and reducing the number of night-time awakenings. Triazolam (0.5 mg) was superior to flurazepam (30 mg) in speeding sleep onset and increasing the quality of sleep. Triazolam (0.25 mg) was preferred to flurazepam (15 mg) and was significantly better than flurazepam on all sleep questions. Triazolam (0.25 mg) was preferred by more patients than flurazepam (30 mg) and was judged equally efficacious on individual sleep questions. Reports of side-effects were minimal for both drugs.

References

Jan 1, 1975·Psychopharmacologia·G VogelK Sexton
Sep 11, 1975·Clinical Pharmacology and Therapeutics·K RickelsA Schilling
Feb 1, 1974·Journal of Clinical Pharmacology·W VeldkampH V Demissianos
Dec 22, 1966·The New England Journal of Medicine·H JickH Muench

Citations

Mar 7, 2006·Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists·Russell P Rosenberg
May 1, 1983·Pharmacotherapy·T RothF Zorick
Mar 1, 1982·Arquivos de neuro-psiquiatria·R Reimão, A B Lefévre
Jul 1, 1983·Drug Intelligence & Clinical Pharmacy·P D Kroboth, R P Juhl
Jul 1, 1982·Journal of Clinical Pharmacology·T RoehrsT Roth

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