Comparative efficacy of various vitamin D metabolites in the treatment of various types of hypoparathyroidism

The Journal of Clinical Endocrinology and Metabolism
K OkanoT Fujita

Abstract

Fourteen patients with pseudohypoparathyroidism, 17 with idiopathic hypoparathyroidism, and 12 with postoperative hypoparathyroidism were treated with vitamin D2, dihydrotachysterol, 1 alpha-hydroxyvitamin D3)1 alpha-OHD3), and 1,25-dihydroxyvitamin D3 for 6-18 months. The optimal maintenance dose or minimum daily dose of 1,25-dihydroxyvitamin D3 to maintain serum calcium at approximately 8.5 mg/100 ml and control all the clinical symptoms was 1.3 +/- 0.16 micrograms/day (mean +/- SE) in pseudohypoparathyroidism, 1.5 +/- 0.18 micrograms/day in idiopathic hypoparathyroidism, and 1.9 +/- 0.50 micrograms/day in postoperative hypoparathyroidism. There was no significant difference in the optimal maintenance dose among the 3 groups. The optimal maintenance dose of 1 alpha-OHD3, however, was 2.0 +/- 0.12 micrograms/day in pseudohypoparathyroidism, significantly lower than that in idiopathic hypoparathyroidism (3.5 +/-0.29 micrograms/day; P less than 0.001) and in postoperative hypoparathyroidism (4.89 +/- 0.54 micrograms/day; P less than 0.001). Significantly lower doses were required in the treatment of idiopathic hypoparathyroidism than in postoperative hypoparathyroidism (P less than 0.05). No significant difference was found in t...Continue Reading

Citations

Jul 25, 2008·The New England Journal of Medicine·Dolores Shoback
Sep 8, 2009·Thyroid : Official Journal of the American Thyroid Association·Vanessa Walker Harris, Suzanne Jan De Beur
Aug 1, 1997·Acta Paediatrica Japonica; Overseas Edition·T Yasuda, H Niimi
Aug 1, 1989·The American Journal of the Medical Sciences·N A Breslau
Jul 3, 2002·Endocrinology and Metabolism Clinics of North America·Jaakko Perheentupa
Jul 15, 2015·European Journal of Endocrinology·Jens BollerslevUNKNOWN European Society of Endocrinology
Sep 24, 2015·Endocrinology and Metabolism·Lars RejnmarkTanja Sikjaer
Jan 14, 1998·The Journal of International Medical Research·Y YamamotoH Kida
Dec 22, 2010·Deutsches Ärzteblatt International·Andreas Schäffler
Jan 1, 1992·Bone and Mineral·K NakatsukaS Murakawa
Sep 18, 2021·Problemy e̊ndokrinologii·E V KovalevaI I Dedov

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