Comparative endocrine disruptive effects of contaminants in ringed seals (Phoca hispida) from Svalbard and the Baltic Sea

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
Heli RouttiGeir Wing Gabrielsen

Abstract

We investigated variables related to thyroid, vitamin A and calcitriol homeostasis, immune function and tumour development in ringed seals (Phoca hispida) from the polluted Baltic Sea and a less polluted reference location at Svalbard, Norway. We also examined the relationships between the biological variables and the concentrations of persistent organic pollutants (POPs) and their hydroxylated (OH) metabolites. Our data show higher plasma concentrations of free triiodothyronine (T3), and ratios of free and total T3 in Baltic seals as compared to Svalbard seals. Baltic seals had also higher hepatic mRNA expressions of deiodinase-I, thyroid hormone receptor beta, retinoic acid receptor alpha, growth hormone receptor and interleukin-1beta compared to Svalbard seals. Levels of plasma retinol were lower in the Baltic seals as compared to Svalbard seals. No geographical difference was observed for other thyroid hormone levels and hepatic retinoid levels. Ratios of free and total T3 were positively correlated to OH-POPs in plasma. The results of the present study suggest that endocrine homeostasis may be affected by contaminant and metabolite exposure in the Baltic ringed seals with respect to circulating hormones and retinol and hep...Continue Reading

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Citations

Apr 18, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Cathy DebierYvan Larondelle
Nov 23, 2015·Environment International·Jean-Pierre W DesforgesRune Dietz
Oct 23, 2014·Biological Reviews of the Cambridge Philosophical Society·Frances Orton, Charles R Tyler
Apr 29, 2015·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Shannon AtkinsonKendall Mashburn
Dec 17, 2017·Acta Veterinaria Scandinavica·Christian SonneRune Dietz
Dec 20, 2019·The Journal of Animal Ecology·Daniel J BeckerRaina K Plowright
Nov 10, 2020·Journal of Hazardous Materials·Ali Ranjbar JafarabadiTiziana Cappello

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