Comparative enzymology, biochemistry and pathophysiology of human exo-alpha-sialidases (neuraminidases)

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
K E Achyuthan, A M Achyuthan

Abstract

This review summarizes the current research on human exo-alpha-sialidase (sialidase, neuraminidase). Where appropriate, the properties of viral, bacterial, and human sialidases have been compared. Sialic acids are implicated in diverse physiological processes. Sialidases, as enzymes acting upon sialic acids, assume importance as well. Sialidases hydrolyze the terminal, non-reducing, sialic acid linkage in glycoproteins, glycolipids, gangliosides, polysaccharides, and synthetic molecules. Therefore, a variety of assays are available to measure sialidase activity. Human sialidase is present in several organs and cells. Its cellular distribution could be cytosolic, lysosomal, or in the membrane. Human sialidase occurs in a high molecular-mass complex with several other proteins, including cathepsin A and beta-galactosidase. Multi-protein complexation is important for the in vivo integrity and catalytic activity of the sialidase. However, multi-protein complexation, the occurrence of isoenzymes, diverse subcellular localization, thermal instability, and membrane association have all contributed to difficulties in purifying and characterizing human sialidases. Human sialidase isoenzymes have recently been cloned and sequenced. Even ...Continue Reading

References

Nov 1, 1979·Journal of Biochemistry·Y UchidaT Sugimori
Aug 15, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·R MinamiT Nakao
Jun 1, 1976·Analytical Biochemistry·J I MurayamaA Hamada
Jan 1, 1978·Methods in Enzymology·R Schauer
Jan 1, 1979·Archives of Oral Biology·R RogersA Tatevossian
Jan 1, 1976·Advances in Experimental Medicine and Biology·G TettamantiA Preti
Sep 15, 1992·European Journal of Biochemistry·R FingerhutE Conzelmann
Jan 1, 1992·Analytical Biochemistry·K OguraC C Sweeley
Dec 16, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·Y TakahashiT Orii
Jun 28, 1991·Biochemical and Biophysical Research Communications·M HiraiwaY Kishimoto
Nov 30, 1990·Biochemical and Biophysical Research Communications·M PotierJ Tranchemontagne
Aug 1, 1989·European Journal of Biochemistry·M ZeiglerG Bach
Nov 25, 1988·Nucleic Acids Research·F Corpet
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·O T MuellerT B Shows
Jan 2, 1987·European Journal of Biochemistry·F W VerheijenH Galjaard
Feb 1, 1988·Prenatal Diagnosis·A C Sewell, B F Pontz
Dec 15, 1988·Biochemical and Biophysical Research Communications·R M D'Agrosa, J W Callahan
Dec 1, 1988·Journal of Clinical Microbiology·C T Pachucki, C Creticos
Jan 1, 1988·Journal of Biochemistry·M HiraiwaT Miyatake
Jan 1, 1987·Enzyme·W R Den TandtS Scharpé
Jan 1, 1987·Methods in Enzymology·R Schauer
May 1, 1987·Journal of Biochemistry·M HiraiwaT Miyatake
Aug 1, 1986·Biological Chemistry Hoppe-Seyler·J C MichalskiR Schauer
Feb 1, 1973·Angewandte Chemie·R Schauer
Jan 1, 1972·Current Topics in Microbiology and Immunology·R Drzeniek

❮ Previous
Next ❯

Citations

Jul 24, 2010·Glycoconjugate Journal·Mark L WarwasMargo M Moore
Mar 2, 2012·Glycobiology·Taeko Miyagi, Kazunori Yamaguchi
May 17, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jeffrey L LarsonFang Fang
Mar 30, 2006·Antimicrobial Agents and Chemotherapy·Michael P MalakhovFang Fang
Jun 4, 2004·Journal of Bacteriology·D R BrownW G Farmerie
Jun 29, 2002·Journal of Clinical Microbiology·Marilyn S HamiltonKomandoor E Achyuthan
Aug 12, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Barry StarcherAlexsander Hinek
Nov 2, 2012·Skeletal Muscle·Alessandro FanzaniEugenio Monti
Oct 31, 2013·International Journal of Vascular Medicine·Norihiko Sasaki, Masashi Toyoda
Apr 18, 2003·Luminescence : the Journal of Biological and Chemical Luminescence·Komandoor E AchyuthanCraig D Shimasaki
Dec 30, 2006·Chembiochem : a European Journal of Chemical Biology·Harshal A ChokhawalaXi Chen
Oct 1, 2011·Chembiochem : a European Journal of Chemical Biology·Roland Schauer, Johannis P Kamerling
Jun 13, 2012·Biological & Pharmaceutical Bulletin·Hyung Jae JeongWoo Song Lee
Mar 14, 2003·Biochimica Et Biophysica Acta·Reinout P HesselinkGer J Van der Vusse
Jan 11, 2016·Biotechnology and Applied Biochemistry·Xuedong WangLong Liu
May 25, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·John GlaspyUNKNOWN Darbepoetin Alfa 20010162 Study Group
Apr 24, 2012·Cellular Microbiology·Amanda L Lewis, Warren G Lewis
Mar 1, 2007·The Journal of Biological Chemistry·Laurent DucaLaurent Debelle
Mar 22, 2007·The Journal of Biological Chemistry·Cristina TringaliBruno Venerando
Jun 13, 2020·Critical Reviews in Biochemistry and Molecular Biology·Andrea Heinz

❮ Previous
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