PMID: 11312806Apr 21, 2001Paper

Comparative evaluation of antioxidant potential of alaternin (2-hydroxyemodin) and emodin

Journal of Agricultural and Food Chemistry
J S ChoiT Yokozawa

Abstract

The antioxidant activities of alaternin (2-hydroxyemodin) and emodin were compared for their respective potentials to inhibit lipid peroxidation in the linoleic acid system by the thiocyanate method, to inhibit total reactive oxygen species generation in kidney homogenates using 2',7'-dichlorodihydrofluorescein diacetate, to inhibit peroxynitrite formation by the 3-morpholinosydnonimine system, which generates superoxide radical and nitrogen monooxide, and to scavenge authentic peroxynitrites. Both alaternin and emodin were found to inhibit the peroxidation of linoleic acid by the thiocyanate method in a dose-dependent manner. Whereas the former shows inhibitory activities in reactive oxygen- and nitogen-mediated reactions, the latter does not. These results indicate that alaternin is a potentially effective and versatile antioxidant and can be used to protect biological systems and functions against various oxidative stresses.

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Citations

Apr 12, 2011·Applied and Environmental Microbiology·Steve S GilesNancy P Keller
Jan 28, 2016·Natural Product Research·Xiao-Song XieShao-Hua Wu
Oct 16, 2004·The Journal of Pharmacy and Pharmacology·Tae Hyun ParkHae Young Chung
Sep 23, 2008·Phytotherapy Research : PTR·Sook Kyung HyunJae Sue Choi
Aug 23, 2008·Journal of Pharmacological Sciences·Benjamin D DreverBettina Platt
Nov 12, 2013·Toxicology and Industrial Health·Hasan Türkez, Elanur Aydın
Aug 31, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Subramanion L JothySreenivasan Sasidharan
Oct 5, 2006·Medicinal Research Reviews·Gopal SrinivasPriya Srinivas
Apr 27, 2019·Bioscience Reports·Wenzhou LiuFeng Miao
Jun 26, 2013·Prikladnaia biokhimiia i mikrobiologiia·N N GesslerT A Belozerskaia
Oct 2, 2013·Toxicology and Industrial Health·Hasan Türkez, Elanur Aydın
Nov 7, 2013·Toxicology and Industrial Health·Zühal PolatAli Aslan
Apr 8, 2020·Physiology and Molecular Biology of Plants : an International Journal of Functional Plant Biology·Niti PathakSuman Lakhanpaul
Jul 27, 2021·Phytochemistry·Ruchi Badoni SemwalAlvaro Viljoen
Aug 23, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Omid YazarluMaede Hasanpour

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