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Comparative evaluation of benzodiazepines for control of soman-induced seizures

Archives of Toxicology

Nov 1, 1999

John H McDonoughT M Shih

PMID: 10650919

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Abstract

This study evaluated the ability of six benzodiazepines to stop seizures produced by exposure to the nerve agent soman. Guinea pigs, previously prepared with electrodes to record electroencephalographic (EEG) activity, were pretreated with pyridostigmine (0.026 mg/kg, i.m.) 30 min befor...read more

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Diazepam
Benzodiazepines Assay
Dose-Response Relationship, Drug
Pro-diazepam
Pralidoxime chloride
Atropinum, atropine
Electroencephalogram
Clonazepam
Pralidoxime
Anticonvulsants
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Comparative evaluation of benzodiazepines for control of soman-induced seizures

Archives of Toxicology

Nov 1, 1999

John H McDonoughT M Shih

PMID: 10650919

DOI:

Abstract

This study evaluated the ability of six benzodiazepines to stop seizures produced by exposure to the nerve agent soman. Guinea pigs, previously prepared with electrodes to record electroencephalographic (EEG) activity, were pretreated with pyridostigmine (0.026 mg/kg, i.m.) 30 min befor...read more

Mentioned in this Paper

Diazepam
Benzodiazepines Assay
Dose-Response Relationship, Drug
Pro-diazepam
Pralidoxime chloride

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Paper Details
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  • Citations38
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  • Citations38
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