Comparative evaluation of biphasic calcium phosphate and biphasic calcium phosphate collagen composite on osteoconductive potency in rabbit calvarial defect

Biomaterials Research
Eun-Ung LeeSeong-Ho Choi

Abstract

The aim of this study was to determine the osteoconductivity of biphasic calcium phosphate collagen composite (BCPC) in rabbit calvarial defect model by comparing with biphasic calcium phosphate (BCP). Four 8 mm diameter bicortical calvarial defects were made in ten rabbits. Each of the defects was randomly assigned and filled with 1) collagen sponge, 2) BCP, 3) BCPC, and 4) nothing as control. The animals were sacrificed at either 2 weeks (n = 5) or 8 weeks (n = 5) healing period. All groups showed wedge shaped new bone formation limited to the area of the defect margin at both healing periods. The amounts of new bone and defect closure were similar among all groups. In the control and collagen sponge group, the center of the defect was depressed by surrounding tissues. In contrast, in BCP and BCPC group, the center of the defect did not depressed and the grafted materials maintained the space. And the augmented area was significantly higher in BCP and BCPC group compared to the control and collagen sponge group at both healing periods (p < 0.05). The BCPC and BCP demonstrated proper space maintaining capacity and osteoconductive property, suggesting BCPC can be efficiently utilized in various clinical situations.

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Citations

Jul 17, 2012·Journal of Endodontics·Mahmoud Reza ModareszadehNarges Salamat
Nov 29, 2016·Macromolecular Bioscience·Chee Meng Benjamin HoYong-Jin Yoon
Oct 14, 2017·Journal of Materials Science. Materials in Medicine·Naga Vijaya Lakshmi ManchinasettyMasanori Kikuchi
Mar 20, 2018·The Journal of Craniofacial Surgery·Majid RezaeiMasih Rezaee
Apr 11, 2019·Journal of Medical Signals and Sensors·Farnoosh Pahlevanzadeh, Mehdi Ebrahimian-Hosseinabadi
Aug 30, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Luanda C LinsJean-François Gérard

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