Comparative evaluation of cefpodoxime versus cefixime in children with lower respiratory tract infections

Indian Journal of Pediatrics
Jayati SenguptaAshok K Moharana

Abstract

The emergence of penicillin and macrolide resistant strains, responsible for Acute Lower Respiratory Tract Infections in children has offered third generation cephalosporins the platform to perform. The aim of the present study was to evaluate two third generation oral cephalosporins for their empirical use in community acquired lower respiratory tract infections in pediatric patients. An assessment of the clinical cure and bacteriological eradication rates and an overall tolerability was made. It was a prospective, open, comparative, multicentric study. 776 children (Mean age 10 years) with LRTIs were included and randomly allotted to two groups respectively. A total of 396 children were given cefpodoxime susp 5 mg/kg b.i.d. and 380 patients on cefixime 4 mg/kg b.i.d. for 10-14 days. At the end of therapy, the clinical success with cefpodoxime was 97% as against 86.8% with cefixime. Bacterial eradication was 93.4% with cefpodoxime and 82.9% with cefixime. Cefpodoxime has been found to be a well-tolerated and superior alternative to cefixime synergistically documenting the extended spectrum of activity.

References

May 1, 1988·Indian Journal of Pediatrics·V P Reddaiah, S K Kapoor
Jun 22, 2002·The Journal of Antimicrobial Chemotherapy·Gian Carlo SchitoJosé Prieto
Jan 31, 2003·The Journal of Antimicrobial Chemotherapy·J PrietoM L Gómez-Lus

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Citations

Feb 13, 2007·Diagnostic Microbiology and Infectious Disease·Isaac F MitropoulosKeith A Rodvold
May 17, 2012·World Journal of Gastrointestinal Surgery·George H SakorafasVasileios Smyrniotis

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