Abstract
Flos Chrysanthemi (FC), a commonly used traditional Chinese medicine, has five major cultivars ("Boju", "Chuju", "Gongju", "Hangbaiju" and "Huaiju") from different sources. However, the active constituents of these cultivars have not been studied or characterized with respect to their bioactivity, which is a serious problem when considering quality and safety. To evaluate the differences among the five cultivars of FC, and to establish a method for the standardization and quality control of FC related to its bioactivity. In this study, the different ingredients in five cultivars of FC were identified by UPLC-Q/TOF and PCA, and the anti-inflammatory ingredients of FC were predicted and screened by artificial neural network (ANN) and an NF-κB luciferase reporter gene assay system. Using this comprehensive method, we successfully screened the anti-inflammatory markers of different cultivars of FC. Nineteen marker ingredients were confirmed to contribute strongly to the cluster, and eleven compounds in the five cultivars of FC were found to exert potential anti-inflammatory effects. Among these compounds, the NF-κB inhibitor activity of apigenin-7-O-6″-malonyl-glucoside, luteolin-7-O-rutinoside, quercetin-7-O-galactoside, quercetin...Continue Reading
References
Apr 21, 1994·Biochimica Et Biophysica Acta·K BaburajS Durani
Jul 17, 2001·Journal of Agricultural and Food Chemistry·M UkiyaM Takido
Dec 23, 2004·Journal of Agricultural and Food Chemistry·Qingcui ChuJiannong Ye
Sep 22, 2005·Nature Reviews. Immunology·Michael Karin, Florian R Greten
Oct 6, 2005·Planta medica·Hyoung Ja Kim, Yong Sup Lee
Mar 2, 2006·Journal of Agricultural and Food Chemistry·Jung-Yi BorGow-Chin Yen
Nov 7, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jia-Ping LaiChoon Nam Ong
Apr 24, 2007·International Journal of Food Microbiology·Bin ShanHarold Corke
Jul 1, 2008·Talanta·Long JiaoHua Li
May 12, 2009·Journal of Ethnopharmacology·Myeong Sook CheonHo Kyoung Kim
Jan 22, 2010·Analytical and Bioanalytical Chemistry·Emilio MarengoFabio Gosetti
Feb 26, 2010·Journal of Asian Natural Products Research·Yuan-Yuan XieChun-Fu Wu
May 22, 2010·Analytical and Bioanalytical Chemistry·Michael A JansenEdith Porter
Sep 22, 2010·Journal of Agricultural and Food Chemistry·Xin-Yan LuSu Zeng
Oct 12, 2010·Journal of Chromatography. a·Jian-Liang ZhouPing Li
May 3, 2011·Journal of Asian Natural Products Research·Huai-Xue MuWei-Lie Xiao
Nov 16, 2011·AMB Express·Chee Wei LimAngelo Visconti
Nov 24, 2011·Journal of Ethnopharmacology·Dongxu HeQiang Xia
Dec 20, 2011·Journal of Chromatography. a·Jing ZengXinmiao Liang
Jan 19, 2012·The British Journal of Nutrition·Maria Antonietta PanaroAntonia Cianciulli
Apr 4, 2012·Expert Opinion on Drug Discovery·Reena Halai, Matthew A Cooper
Jun 27, 2012·Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association·Anson C Y TangThomas K S Wong
Sep 12, 2012·Analytical and Bioanalytical Chemistry·Binfeng ChengGang Bai
Dec 15, 2012·Fitoterapia·Lulu GengXiaohui Chen
Jan 12, 2013·Phytochemistry·Kan'ichiro IshiuchiDavid R Gang
Feb 28, 2013·The Analyst·Xiao-Lan ChengPing Li
Mar 6, 2013·BioFactors·Yosuke NishitaniMasashi Mizuno
Mar 8, 2013·Journal of Agricultural and Food Chemistry·Boyan GaoLiangli Lucy Yu
Jun 19, 2013·Toxicology·Robert DomitrovićMarko Škoda
Jul 31, 2013·Journal of Chromatography. a·Chaoyang MaHongxin Wang
Aug 30, 2013·Biological & Pharmaceutical Bulletin·Sung Chul KwakJaemin Oh
Nov 20, 2013·Experimental Lung Research·Susana Romero-GarciaJose Sullivan Lopez-Gonzalez
Nov 28, 2013·Talanta·Yao QiZhiqiang Liu
Dec 18, 2014·Experimental Lung Research·Benjamin LopezVedang A Londhe
May 24, 2015·Journal of Ethnopharmacology·Jinjun WuLinlin Lu
Citations
Sep 20, 2016·Journal of Pharmaceutical and Biomedical Analysis·Guoyu DingGang Bai
Dec 4, 2016·Journal of Chromatographic Science·Meng-Zhe GuoDao-Quan Tang
Dec 25, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Mengge ZhouGang Bai
Aug 4, 2020·Natural Product Research·Xi LeiPeng Zhang
Nov 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuxiao WangYuanying Ni
Jan 18, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuxiao WangYuanying Ni
Sep 10, 2020·BioMed Research International·Qi JiaJun He
Oct 9, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yinji ZhuKang Chen
Apr 30, 2021·Chinese Medicine·Wei WeiXinsheng Yao
May 11, 2021·Frontiers in Pharmacology·Jiao HeQing Li
Jun 19, 2021·Chemistry & Biodiversity·Le ChenDahui Liu
Aug 24, 2021·Frontiers in Chemistry·Xiangwei ChangJinao Duan