Comparative evaluation of dynamic contrast-enhanced perfusion with diffusion tensor imaging metrics in assessment of corticospinal tract infiltration in malignant glioma

Journal of Computer Assisted Tomography
R AwasthiR K Gupta

Abstract

To compare dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) with diffusion tensor imaging (DTI) for predicting tumor infiltration in a conventional MRI normal-appearing internal capsule adjacent to the tumor in patients with glioblastoma multiforme. Thirty patients with glioblastoma multiforme underwent a neurological examination for motor assessment, DCE MRI, and DTI. On fused DCE and DTI images, regions of interest were placed on the normal-appearing internal capsule and the corresponding region of the contralateral internal capsule. These patients were pooled into group 1 (improved after surgery, n = 9) and group 2 (did not improve after surgery, n = 21) on the basis of motor strength. The DTI and perfusion metrics were statistically analyzed to look for a predictor of motor functionality. Multivariate logistic regression analysis showed only cerebral blood volume to be the predictor of improvement in motor functionality after surgery (P = 0.043). We conclude that cerebral blood volume appears to be the predictor of motor functionality after surgery and may indirectly suggest tumor infiltration, whereas DTI helps to precisely localize the fiber tracts.

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Citations

Feb 5, 2013·Neuroradiology·Bhaswati RoyJeffry R Alger
Feb 18, 2011·Current Neurology and Neuroscience Reports·Jonathan H ShermanPhilip H Gutin
Jul 27, 2012·Neuroscience Bulletin·Nianming ZuoTianzi Jiang
Feb 1, 2012·The Cancer Journal·Jennifer A MoliternoJoseph M Piepmeier
Jan 5, 2012·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Naomi MoritaElias R Melhem
Feb 1, 2014·AJNR. American Journal of Neuroradiology·A A MaudsleyS Behari
Oct 1, 2010·Journal of Magnetic Resonance Imaging : JMRI·Sona SaksenaTom Mikkelsen
Oct 19, 2011·Journal of Magnetic Resonance Imaging : JMRI·B RoyR K Gupta

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