PMID: 9542910May 23, 1998Paper

Comparative evaluation of FUNGITEST and broth microdilution methods for antifungal drug susceptibility testing of Candida species and Cryptococcus neoformans

Journal of Clinical Microbiology
K G DaveyDavid W Warnock

Abstract

The FUNGITEST method (Sanofi Diagnostics Pasteur, Paris, France) is a microplate-based procedure for the breakpoint testing of six antifungal agents (amphotericin B, flucytosine, fluconazole, itraconazole, ketoconazole, and miconazole). We compared the FUNGITEST method with a broth microdilution test, performed according to National Committee for Clinical Laboratory Standards document M27-A guidelines, for determining the in vitro susceptibilities of 180 isolates of Candida spp. (50 C. albicans, 50 C. glabrata, 10 C. kefyr, 20 C. krusei, 10 C. lusitaniae, 20 C. parapsilosis, and 20 C. tropicalis isolates) and 20 isolates of Cryptococcus neoformans. Overall, there was 100% agreement between the methods for amphotericin B, 95% agreement for flucytosine, 84% agreement for miconazole, 83% agreement for itraconazole, 77% agreement for ketoconazole, and 76% agreement for fluconazole. The overall agreement between the methods exceeded 80% for all species tested with the exception of C. glabrata (71% agreement). The poorest agreement between the results for individual agents was seen with C. glabrata (38% for fluconazole, 44% for ketoconazole, and 56% for itraconazole) and C. tropicalis (50% for miconazole). The FUNGITEST method miscla...Continue Reading

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Citations

Jul 31, 2004·Drug Metabolism and Drug Interactions·Berrin OzçelikFikri Içli
Oct 22, 2005·Oral Microbiology and Immunology·T KuriyamaM A O Lewis
Dec 9, 2014·Jundishapur Journal of Microbiology·Pedram HaddadiHadis Jafarian
Oct 5, 2001·Clinical Microbiology Reviews·J H RexD W Warnock
Oct 5, 2015·Journal of Industrial Microbiology & Biotechnology·Louis K Ho, Justin R Nodwell
Nov 7, 2001·Revista Do Instituto De Medicina Tropical De São Paulo·S H AlvesM H Vainstein
Feb 29, 2020·Archives of Microbiology·M F GhalyM M Bendary
Feb 2, 2021·Infectious Diseases and Therapy·Francelise B CavassinFlávio Queiroz-Telles
Sep 28, 2002·Biochimica Et Biophysica Acta·Eva J HelmerhorstFrank G Oppenheim
Aug 6, 2005·Journal of Clinical Microbiology·Luis Octavio Sánchez-VargasGuillermo Quindós
Jan 10, 2002·Infectious Disease Clinics of North America·M A Pfaller, W L Yu

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