Comparative Evaluation of Hepatoprotective Activities of Geniposide, Crocins and Crocetin by CCl4-Induced liver Injury in Mice

Biomolecules & Therapeutics
Ping ChenHao Zhang

Abstract

Iridoid glycosides (mainly geniposide) and crocetin derivatives (crocins) are the two major active constituents in Gardenia jasminoides Ellis. In the present study, geniposide, crocins, crocin-1 and crocetin were separated from gardenia chromatographically. Then, mice were orally administrated with geniposide (400 mg/kg b.w.), crocins (400 mg/kg b.w.), crocin-1 (400 mg/kg b.w.) and crocetin (140 mg/kg b.w.) once daily for 7 days with CCl4. Hepatoprotective properties were evaluated by biochemical parameters: Administration of geniposide, crocins, crocin-1and crocetin significantlylowered serum alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) levels in CCl4-treated mice. The reduced glutathione (GSH) levels and antioxidant enzymes (SOD and CAT) activities were also increased by geniposide, crocins, crocin-1 and crocetin. Histopathological examination of livers showed that these components reduced deformability, irregular arrangement and rupture of hepatocyte in CCl4-treated mice. These biochemical results and liver histopathological assessment demonstrated that geniposide, crocetin derivatives and crocetin show comparative beneficialeffects on CCl4-induced liver damage via induction of anti...Continue Reading

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Citations

Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ziya Taner OzkececiAhmet Bal
Oct 30, 2016·British Journal of Pharmacology·Alireza MilaniAzam Bolhassani
Oct 11, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mingqiu ShanSam Fong Yau Li
Sep 21, 2019·Journal of Biomolecular Structure & Dynamics·S Ali HashemiMohammad-Ali Mohagheghi
Jul 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xin CheHui Xu
Feb 7, 2020·Phytotherapy Research : PTR·Xiao MaYanling Zhao
Aug 6, 2020·Viruses·Gopinathan Pillai SreekanthThawornchai Limjindaporn
Nov 2, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chunnan LiJiaming Sun
Mar 26, 2021·Phytotherapy Research : PTR·Min WenYining Lin
Apr 20, 2021·Mediators of Inflammation·Yi-Ling WenSi Qin
Apr 28, 2019·Journal of Ethnopharmacology·Angelica VestenaGilsane von Poser

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