Comparative evaluation of humic substances in oral drug delivery

Results in Pharma Sciences
Mohd Aamir MirzaZeenat Iqbal

Abstract

Major and biologically most explored components of natural organic matter (NOM) are humic acid (HA) and fulvic acid (FA). We have explored rock shilajit as a source of NOM. On the other hand carbamazepine (CBZ) is a well known anticonvulsant drug and has a limited accessibility to brain. Bioavailability and pharmacokinetic profiles of CBZ have been improved by complexation and different techniques also. Present study has assessed the comparative abilities of FA and HA as complexing agent for CBZ in order to enhance pharmacokinetic profile of CBZ and accessibility to the brain. These two complexing agents have been compared on various indices such as their abilities to cause complexation and enhance solubility, permeability and dissolution. The present study also compared pharmacodynamic and biochemical profiles after oral administration of complexes. With the help of various pharmaceutical techniques such as freeze drying, physical mixture, kneading and solvent evaporation, two molar ratios (1:1 and 1:2) were selected for complexation and evaluated for conformational analysis (molecular modeling). Complex formed was further characterized by differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR)...Continue Reading

Citations

Jan 10, 2014·Drug Delivery·Amol D ThingaleChellampillai Bothiraja
Oct 3, 2018·Journal of Diabetes Research·John Winkler, Sanjoy Ghosh
Mar 29, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria V ZykovaMark T Quinn
May 25, 2021·Chemical Society Reviews·Fan YangMarkus Antonietti

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