PMID: 8938848Nov 1, 1996Paper

Comparative evaluation of impulse oscillometry and a monofrequency forced oscillation technique in clinically healthy calves undergoing bronchochallenges

Research in Veterinary Science
P ReinholdPierre Lekeux

Abstract

Multifrequency impulse oscillometry (IOS) was compared with a monofrequency forced oscillation technique (MFO) in calves undergoing experimentally induced bronchoconstriction and subsequent bronchodilatation. The dynamic lung compliance (Cdyn) was also measured by conventional methods. For each test, the baseline mean and the responses to saline, a bronchoconstrictive agent (carbachol) and a bronchodilator (fenoterolhydrobromide) were calculated. Using the IOS, the information was markedly frequency-dependent. The resistance (R) and the magnitude of respiratory impedance (Z) were only sensitive at 5 Hz, leading to negative frequency dependence of these parameters as an indicator of peripheral airway obstruction. A high sensitivity for reactance (X) and phase angle phi values was observed between 5 and 20 Hz. For MFO (10 Hz), the parameters Ros (which includes resistive and capacitive components of the respiratory system), phase shift (psi), and the oscillatory derived compliance of the respiratory system (Crs) were of the greatest clinical potential. Crs showed a significant coefficient of linear correlation (r = 0.88, P < 0.001) with Cdyn. At the 10 Hz test frequency similar results were observed with MFO and IOS, suggesting t...Continue Reading

References

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Citations

Nov 20, 2001·Medical & Biological Engineering & Computing·D MacLeod, M Birch
Aug 10, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·M KohlhäuflJ Heyder
Nov 19, 2003·American Journal of Veterinary Research·Emmanuelle van ErckPierre Lekeux
Jun 13, 2006·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·P ReinholdC Schroeder
Apr 19, 2015·BMC Veterinary Research·Krister BlodörnJean François Valarcher
Feb 24, 2000·Research in Veterinary Science·C H UystepruystP Lekeux
Aug 19, 2009·Environmental Management·Cheryl L Wagner, Maria E Fernandez-Gimenez
Jun 23, 2010·Environmental Management·Daniel LavenNora Mitchell
Nov 8, 2002·Journal of the American Veterinary Medical Association·Melinda A FryeJanice M Bright
Feb 6, 2004·Equine Veterinary Journal·E van ErckP Lekeux

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