Comparative evaluation of midazolam and butorphanol as oral premedication in pediatric patients.

Journal of Anaesthesiology, Clinical Pharmacology
Chandni SinhaMadhusudan Upadya

Abstract

To compare oral midazolam (0.5 mg/kg) with oral butorphanol (0.2 mg/kg) as a premedication in 60 pediatric patients with regards to sedation, anxiolysis, rescue analgesic requirement, and recovery profile. In a double blinded study design, 60 pediatric patients belonging to ASA class I and II between the age group of 2-12 years scheduled for elective surgery were randomized to receive either oral midazolam (group I) or oral butorphanol (group II) 30 min before induction of anesthesia. The children were evaluated for levels of sedation and anxiety at the time of separation from the parents, venepuncture, and at the time of facemask application for induction of anesthesia. Rescue analgesic requirement, postoperative recovery, and complications were also recorded. Butorphanol had better sedation potential than oral midazolam with comparable anxiolysis at the time of separation of children from their parents. Midazolam proved to be a better anxiolytic during venepuncture and facemask application. Butorphanol reduced need for supplemental analgesics perioperatively without an increase in side effects such as nausea, vomiting, or unpleasant postoperative recovery. Oral butorphanol is a better premedication than midazolam in children ...Continue Reading

References

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Citations

Mar 5, 2015·Experimental Animals·Atsushi TsukamotoTomo Inomata
Feb 16, 2016·Experimental Animals·Atsushi TsukamotoTomo Inomata
Jan 21, 2017·Journal of Avian Medicine and Surgery·Marie KubiakKevin Eatwell
Jul 1, 2017·Journal of Developmental and Behavioral Pediatrics : JDBP·Cheryl H T ChowNorman Buckley
Jun 15, 2016·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Mirjam N LandgrafFlorian Heinen

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Methods Mentioned

BETA
sedation

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