PMID: 636802Jan 1, 1978

Comparative evaluation of neuro-muscular blockade after pancuronium administration in patients with and without renal failure

Acta Anaesthesiologica Scandinavica
A d'HollanderM Sanders

Abstract

Objective studies about the duration of action pancuronium (PCM) in renal failure patients are scarce. This study was undertaken to obtain more complete information on spontaneous reversal from PCM-induced neuromuscular block by monitoring the twitch height to full recovery in the absence of any potentiating agent. Thumb abduction was monitored by a deplacement transducer in end-stage renal failure (ESRF) and in control patients without renal failure (RF) during neuroleptanalgesia after 0.04 mg/kg and 0.08 mg/kg PCM administration. In the small dosage series, the prologation of action in ESRF becomes significant for the 75% recovery level (mean values +/- s.e.mean:control: 42 +/- 7 min, ESRF: 71 +/- 10 min, P less than or equal to 0.05). In the second series (0.08 mg/kg), the 50% recovery level is already significantly delayed in ESRF patients (control: 91 +/- 7 min, ESRF: 163 +/- 27 min, P less than or equal to 0.05). The 100% twitch height recovery is obtained with 0.04 mg/kg PCM within 65+/- 7 min for patients without RF and within 103 +/- 9 min in ESRF patients (P less than or equal to 0.01). For the 0.08 mg/kg PCM dose, these figures are, respectively, 139 +/- 9 min and 214 +/- 20 min (P less than or equal to 0.01). The pr...Continue Reading

References

Jan 1, 1978·Acta Anaesthesiologica Scandinavica·F Camu, A d'Hollander
Mar 1, 1976·British Journal of Anaesthesia·R D Miller, D J Cullen
Apr 1, 1976·British Journal of Anaesthesia·K McLeodM D Rawlins
May 1, 1970·European Journal of Pharmacology·D K Meijer, J G Weitering
Sep 1, 1971·Anesthesia and Analgesia·J W McIntyre, E A Gain
Oct 1, 1971·British Journal of Anaesthesia·J StovnerE Bjelke
Nov 1, 1972·British Journal of Anaesthesia·S Kamvyssi-DeaP Dousaitou
Jan 1, 1973·Acta Anaesthesiologica Scandinavica·S AgostonD K Meijer
Jan 1, 1974·Anesthesiology·M D Sokoll
Feb 1, 1972·British Journal of Anaesthesia·M GibaldiW L Hayton
Jun 1, 1969·Anesthesiology·S A FeldmanR C Golling
Mar 1, 1967·Anesthesiology·E N CohenD Smith

Citations

Jan 1, 1983·European Journal of Clinical Pharmacology·A A d'HollanderJ M Desmonts
Jan 1, 1981·European Journal of Clinical Pharmacology·D R BevanR L Smith
Dec 1, 1981·The Australian and New Zealand Journal of Surgery·J Gomez-ArnauF Avello
Nov 1, 1983·Anaesthesia and Intensive Care·P J Maddern
Aug 1, 1979·Anaesthesia and Intensive Care·C A ShanksE J Triggs
Feb 1, 1980·Anaesthesia and Intensive Care·C A ShanksE J Triggs

Related Concepts

Drug Evaluation
Kidney Failure, Chronic
Nerve Block
Nerve-Muscle Preparation
Pancuronium Curamed

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