Comparative evaluation of potential components for group B meningococcal vaccine by passive protection in the infant rat and in vitro bactericidal assay

Vaccine
K SaukkonenJan T Poolman

Abstract

Seventeen monoclonal antibodies to one of three main cell surface antigens of Neisseria meningitidis group B were tested for protective efficacy in the infant rat using as challenge seven strains of different class 2/3 protein serotypes, class 1 protein (P1) subtypes and LPS immunotypes. Type-specific protection indicated both by a reduction of bacteraemia and meningitis and survival of the animals was regularly obtained with antibodies to the P1 protein and to LPS. By contrast, only one of seven antibodies to the serotype-specific class 2/3 protein was protective, even though four of them were highly bactericidal. The animal protection test and in vitro bactericidal assay were otherwise concordant. These data form important guidelines for the design of vaccines to prevent group B meningococcal infections.

References

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Citations

Jan 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·P H Mäkelä
Jan 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·J T Poolman
Jan 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·W D Zollinger, E Moran
Sep 25, 1999·FEMS Immunology and Medical Microbiology·A S JohnsonA Robinson
Feb 23, 2000·FEMS Immunology and Medical Microbiology·C JansenJ Tommassen
Sep 25, 2002·Molecular Biology and Evolution·Rachel UrwinMartin C J Maiden
Jan 1, 1993·The Journal of Applied Bacteriology·A Robinson, J Melling
May 1, 1995·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A Z Henriksen, J A Maeland
Nov 18, 2000·Infection and Immunity·A van der EndeJ Dankert
Feb 21, 2002·Infection and Immunity·Svein Rune AndersenSimon Y C Wong

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