Comparative evaluation of role of hs C -reactive protein as a diagnostic marker in chronic periodontitis patients

Journal of Family Medicine and Primary Care
Shivangi GuptaNiraliben Patel

Abstract

C-reactive protein (CRP) is a type I acute phase protein, which can increase up to 1000 fold after the onset of a stimulus. It is a phylogenetically highly conserved plasma protein with homolog in vertebrates and many invertebrates that participate in systemic response to inflammation. Serum C-reactive protein levels are raised in patients with myocardial infarction and periodontitis, providing a potential mechanism to link destructive periodontal disease with an increased risk for other atherosclerotic complications. The purpose of the present study was to estimate and compare the levels of hs- C Reactive protein in chronic periodontitis patients before and after non-surgical periodontal therapy. The study sample consisted of 45 individuals of age group 30-60 years that was divided into two groups Group I (control) and Group II (patients with chronic generalized periodontitis). The clinical parameters such as plaque index, calculus index, gingival index, probing pocket depth, clinical attachment level, and serum hs-CRP levels were recorded for these individuals. The patients with healthy gingiva possessed a mean hs-CRP level of 0.252 ± 0.0393 which was lower as compared to the patients with chronic periodontitis. In periodonti...Continue Reading

References

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Citations

Feb 2, 2021·Frontiers in Cardiovascular Medicine·Faraedon ZardawiJulian Yates
Apr 4, 2021·International Journal of Environmental Research and Public Health·Biagio RaponeAntonio Scarano
Jan 22, 2022·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Linith Valiyaveetil KarattilJayan Jacob Mathew

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Methods Mentioned

BETA
Enzyme linked immunosorbent assay
ELISA

Software Mentioned

Statistical Package for Scientific Studies ( SPSS

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