Mar 1, 1975

Comparative evaluation of the antitoxic activity of central nervous system analeptics and their combinations in barbamyl poisoning

Farmakologiia i toksikologiia
A V Stanishevskaia, A N Kudrin

Abstract

Tests conducted on rats poisoned with increasingly lethal doses of sodium amytal demonstrated the antitoxic activity of an analeptic mixture to be superior to that of picrotoxin, strichnine, corasol and caffeine entering into its composition and also to the activity of bemegride. As to the degree of antitoxic activity in poisoning of mice with sodium amytal (one LD50) the CNS analeptics are arranged in the following descending oder of their action: analeptic mixture, picrotoxin, bemegride, corasol, strychnine. In poisoning with higher doses of sodium amytal (LD84) corasol, strychnine and caffeine are ineffective, the most productive being analeptic mixture and picrotoxin. Bemegride proves effective only in a single dose of 2.8 LD50 for intact animals.

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Mentioned in this Paper

DRUG Screen Quant Caffeine
Central Nervous System Stimulants
Strychnine Assay
Megimide
Thyramine
Quick-Pep
Picrotoxin
Corasol
Entire Central Nervous System
Poisoning Aspects

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