Abstract
In an open randomized study 218 outpatients (159 males and 59 females) ranging between 18 and 85 years of age (mean 61.9) suffering from bacterial exacerbation of chronic bronchitis have been randomly treated: 79 with co-amoxiclav (amoxicillin 875 mg+clavulanic acid 125 mg) twice daily, 69 with cefixime (400 mg) once daily, and 70 with ciprofloxacin (500 mg) twice daily for an average period of 10 days. Before treatment start, 234 bacterial strains (105 Gram-positive and 129 Gram-negative) were isolated as the cause of exacerbation; the leading pathogens were Streptococcus pneumoniae and Haemophilus spp. Eradication rates at the end of treatment were 82.2% for the co-amoxiclav group, 77.6% for the cefixime group, and 81.2% for ciprofloxacin group. Clinical success (cure+improvement) was obtained in 90.8% of the cases treated with co-amoxiclav, in 80.9% for the cefixime group and in 85.7% of patients treated with ciprofloxacin. Seven adverse events (8.9%) of which 4 cases of diarrhea and 3 of itching, were recorded in the co-amoxiclav group. Eleven adverse events (14.7%) were recorded in the cefixime group including gastrointestinal disturbances in 6 patients and mild to moderate increase of liver function in 2. Nine adverse eve...Continue Reading
References
Nov 1, 1978·Antimicrobial Agents and Chemotherapy·H C Neu, K P Fu
Mar 13, 1975·The New England Journal of Medicine·I Tager, F E Speizer
Aug 1, 1992·Journal of Chemotherapy·M B PellegrinoG Nicoletti
Oct 1, 1992·The Journal of Antimicrobial Chemotherapy·P Y LiuD M Livermore
Oct 1, 1989·Drugs·R N Brogden, D M Campoli-Richards
Apr 1, 1986·European Journal of Clinical Microbiology·B I DaviesC Baur
Apr 1, 1988·Drugs·D M Campoli-RichardsA Ward
Jan 1, 1987·Drugs·C GrassiP Mangiarotti
Feb 1, 1987·Annals of Internal Medicine·N R AnthonisenN A Nelson
Mar 1, 1987·The Journal of Antimicrobial Chemotherapy·F P MaesenC Baur
Jul 1, 1987·The American Review of Respiratory Disease
Nov 1, 1985·Clinical Pharmacology and Therapeutics·D C BrittainH C Neu
Dec 1, 1984·The Journal of Antimicrobial Chemotherapy·F P MaesenJ P Teengs
Mar 22, 1980·Lancet·A P BallG R Brookes
Mar 1, 1980·The Journal of Antimicrobial Chemotherapy·R WiseK A Bedford
Jun 1, 1994·Pulmonary Pharmacology·M Cazzola
Oct 1, 1994·Journal of Chemotherapy·G N Rolinson
Jan 1, 1993·Respiration; International Review of Thoracic Diseases·W Cullmann
Dec 1, 1992·International Journal of Antimicrobial Agents·J C Yernault, D Russell
Citations
Dec 24, 2004·Antimicrobial Agents and Chemotherapy·Sanjay SethiBrian Wynne
Dec 1, 2001·Clinical Therapeutics·E M PerfettoJ Li-McLeod
Oct 3, 1998·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P LéophonteN Pluck
Aug 28, 1999·Respiratory Medicine·R C ReadR Kubin
Dec 10, 1999·The Journal of Antimicrobial Chemotherapy·R WilsonB Sommerauer
Aug 28, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·G A Luzzi