Comparative evaluation of the effect of tricyclic antidepressants on inducible nitric oxide synthase expression in neuropathic pain model

Nitric Oxide : Biology and Chemistry
Hanan Sayed Mohamed FarghalyHassan Ibrahim Kotb

Abstract

The analgesic effect of acute i.p. administration of amitriptyline (norepinepherine and serotonin reuptake inhibitor), clomipramine (serotonin reuptake inhibitor) and desipramine (norepinepherine reuptake inhibitor) was studied in chronic constriction injury (CCI) model of sciatic nerve in rats and mRNA and protein expression of inducible nitric oxide synthase (iNOS) were also investigated. Acute treatment with amitriptyline and clomipramine produced antinociceptive effects after sciatic nerve injury and blockade of norepinephrine reuptake using desipramine did not demonstrate antinociceptive effects. The antinociceptive effect of amitriptyline, not clomipramine, was augmented by the selective iNOS inhibitor, aminoguanidine. Amitriptyline inhibited iNOS mRNA and protein expression in cerebellum and hippocampus. However, desipramine altered neither iNOS expression at mRNA level nor at post-transcriptional level. Based on our experimental findings, we conclude that the analgesic effect of the dual norepinepherine and serotonin reuptake inhibitor, amitriptyline, is partially due to inhibition of central iNOS.

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Citations

Dec 22, 2012·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Shyam KaulaskarUday Harle
Oct 10, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Alvaro MoreiraRafael Fonseca
Aug 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Vasiliki MitsiVenetia Zachariou
Mar 7, 2017·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Pere Boadas-VaelloEnrique Verdú
Aug 9, 2017·Canadian Journal of Physiology and Pharmacology·Behnam GhorbanzadehSoheila Alboghobeish

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