Comparative evaluation of the effects of Withania somnifera with pentoxifylline on the sperm parameters in idiopathic male infertility: A triple-blind randomised clinical trial

Andrologia
R Nasimi Doost AzgomiA Zomorrodi

Abstract

In this triple-blind randomised clinical trial, we compared the effects of Withania somnifera and pentoxifylline on the sperm parameters in idiopathic male infertility. One hundred infertile male patients were randomly allocated into either W. somnifera or pentoxifylline groups. Patients in the herbal group received six capsules containing 5 g/daily of W. somnifera root, and subjects in the pentoxifylline group received six capsules containing 800 mg/daily of pentoxifylline and placebo for 90 days. Sperm parameters were analysed at the beginning and end of the study. W. somnifera increased mean sperm count (12.5%) and progressive motility (21.42%) and improved sperm morphology (25.56%) compared to the baseline (p = .04, p = .001 and p = .000 respectively). Moreover, pentoxifylline increased mean semen volume (16.46%), progressive motility (25.97%) and improved sperm morphology (13.28%) versus the baseline (p = .02, p = .003 and p = .01 respectively). Intergroup comparison showed no significant differences between the two groups regarding semen volume (p = .11), sperm count (p = .09), morphology (p = .12) and progressive motility (p = .77) after treatment. No major complication was reported in either of the two groups. W. somnif...Continue Reading

References

Jun 1, 1991·British Journal of Clinical Pharmacology·M R ShenS S Chen
Jan 1, 1986·Journal of Pharmaceutical Sciences·R V SmithH B Lassman
May 16, 2002·Fertility and Sterility·Ira D SharlipRichard Sadovsky
Oct 1, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Abbas Ali MahdiDeepansh Dalela
Nov 26, 2009·Human Reproduction Update·Trevor G CooperKirsten M Vogelsong
Sep 18, 2012·Biochemical Pharmacology·Wim Vanden BergheKaren Heyninck
Jun 26, 2013·Journal of Ethnopharmacology·Ashish GuptaSatya Narain Sankhwar
Dec 29, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Vijay R AmbiyeAtul Dongre
Jun 15, 2016·Journal of Ayurveda and Integrative Medicine·Shruti B PatelLal L Hingorani
Dec 27, 2017·Reproductive Biomedicine Online·Pallav SenguptaRalf Henkel
Apr 20, 2018·BioMed Research International·Ramin Nasimi Doost AzgomiYadollah Ahmadi AsrBadr

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Citations

Nov 17, 2019·International Journal of Molecular Sciences·Rinku DuttaSubhra Mohapatra

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