Comparative evaluation of three antifungal susceptibility test methods for Candida albicans isolates and correlation with response to fluconazole therapy.

Journal of Clinical Microbiology
M RuhnkeM Trautmann

Abstract

In vitro susceptibilities were determined for 56 Candida albicans isolates obtained from the oral cavities of 41 patients with human immunodeficiency virus infection. The agents tested included fluconazole, itraconazole, ketoconazole, flucytosine, and amphotericin B. MICs were determined by the broth microdilution technique following National Committee for Clinical Laboratory Standards document M27-P (M27-P micro), a broth microdilution technique using high-resolution medium (HR micro), and the Etest with solidified yeast-nitrogen base agar. The in vitro findings were correlated with in vivo response to fluconazole therapy for oropharyngeal candidiasis. For all C. albicans isolates from patients with oropharyngeal candidiasis not responding to fluconazole MICs were found to be > or = 6.25 micrograms/ml by the M27-P micro method and > or = 25 micrograms/ml by the HR micro method as well as the Etest. However, for several C. albicans isolates from patients who responded to fluconazole therapy MICs found to be above the suggested breakpoints of resistance. The appropriate rank order of best agreement between the M27-P micro method and HR micro method was amphotericin B > fluconazole > flucytosine > ketoconazole > itraconazole. The...Continue Reading

References

Sep 1, 1992·Antimicrobial Agents and Chemotherapy·M A PfallerD W Warnock
Dec 11, 1992·Journal of Clinical Microbiology·A Espinel-IngroffM G Rinaldi
Aug 1, 1994·Diagnostic Microbiology and Infectious Disease·A Espinel-Ingroff
Feb 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S ReddingM Pfaller
Jan 1, 1996·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C QueredaF Baquero

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Citations

Dec 7, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M FleischhackerM Ruhnke
Sep 6, 2020·Acta Crystallographica. Section C, Structural Chemistry·Luz ArancibiaFlorencia Di Salvo
Sep 19, 2000·Antimicrobial Agents and Chemotherapy·K W HenryT D Edlind
Oct 9, 2002·Molecular Microbiology·Thomas EdlindJoseph Nickels
Aug 16, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·David W. WarnockRen-Kai Li
Jan 9, 1998·Infectious Disease Clinics of North America·A Espinel-Ingroff

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