Comparative evaluation of toxicological effects and recovery patterns in zebrafish (Danio rerio) after exposure to phosalone-based and cypermethrin-based pesticides

Ecotoxicology and Environmental Safety
Volkan KorkmazMurat Ozmen

Abstract

This study evaluated the toxic effects and recovery patterns in zebrafish (Danio rerio) after exposure to phosalone-based (PBP) and cypermethrin-based (CBP) pesticides. Initially, the 96 h LC50 values of the pesticides were calculated as being 5.35 µg of active ingredient (AI) L-1 for CBP and 217 µg AI L-1 for PBP based on measured concentrations. Accordingly, experimental groups were exposed to three sublethal concentrations of pesticides for 96 h, separately, and then zebrafish were transferred to pesticide-free conditions for 10 and 20 days recovery periods. Biochemical markers were assessed including carboxylesterase (CaE), acetylcholinesterase (AChE), glutathione S-transferase (GST), lactate dehydrogenase, glutathione peroxidase, catalase, alanine and aspartate aminotransferase (ALT, AST) activities after the exposure and recovery periods. Also, the pesticide concentrations in test water were quantified by high-performance liquid chromatography (HPLC) analysis. Our results showed that AChE and CaE activities were significantly inhibited and GST was induced by both pesticides after 96 h exposure. For PBP exposure, the decreases for GST induction and CaE inhibition showed a partial recovery in pesticide-free conditions. Howe...Continue Reading

Citations

Sep 18, 2020·Environmental Science and Pollution Research International·Camila F RutkoskiMarilia T Hartmann
Jul 1, 2020·Environmental Science and Pollution Research International·Aysel Alkan Uçkun, Özden Barım Öz
Feb 5, 2021·Neurotoxicology and Teratology·Mehdi AliomraniZahra Sayahpour
Dec 9, 2020·Toxicology Mechanisms and Methods·Jalal HassanA Wallace Hayes
May 15, 2021·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Zohre KhodabandehMehdi Aliomrani
Nov 20, 2018·International Journal of Biological Macromolecules·Kadir ErolDursun Ali Köse

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