Comparative evaluation of two doses of tranexamic acid used prophylactically in anemic parturients for lower segment cesarean section: A double-blind randomized case control prospective trial

Saudi Journal of Anaesthesia
Upasana GoswamiSavita Babbar

Abstract

Postpartum hemorrhage (PPH) and anemia thereafter can be a life threatening condition in parturients undergoing lower segment cesarean section (LSCS), especially when anemia is present. The objective of this study was to assess two doses of Tranexamic acid (TXA) in reducing intra operative blood loss and incidence of PPH, in terms of both efficacy and safety profiles, when used prophylactically. A monocenter prospective case control double blind randomized study was carried out on a consecutive series of 90 anemic patients undergoing LSCS, with hemoglobin between 7-10 g percent. Three random groups were formed. Group T1 (n=30) received 10mg/kg TXA in 20 ml of 5% dextrose intravenously, while T2 group (n=30) received 15mg/kg. Group C (n=30) received a placebo. Drug was administered prophylactically 20 min before skin incision. Blood loss was measured from placental delivery up to 24 hours by method of weight and volume. To compare quantitative data between two groups, t-test, and for more than two groups ANOVA was used. To compare the mean for non- parametric data between two groups Mann - Whitney test was used, while in case of more than two groups Kruskal - Wallis test was employed. Probability (p) value was considered signifi...Continue Reading

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Citations

Dec 19, 2013·Saudi Journal of Anaesthesia·Anne-Sophie Ducloy-Bouthors
Dec 3, 2014·Journal de gynécologie, obstétrique et biologie de la reproduction·A G AyaJ-C Gris
Dec 3, 2014·Journal de gynécologie, obstétrique et biologie de la reproduction·C DupontC Huissoud
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Feb 11, 2015·Acta Obstetricia Et Gynecologica Scandinavica·Kim EkelundArash Afshari
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Methods Mentioned

BETA
cesarean section

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