Comparative evaluation of vaccine efficacy of recombinant Marek's disease virus vaccine lacking Meq oncogene in commercial chickens

Vaccine
Lucy F LeeSanjay M Reddy

Abstract

Marek's disease virus (MDV) oncogene meq has been identified as the gene involved in tumorigenesis in chickens. We have recently developed a Meq-null virus, rMd5 Delta Meq, in which the oncogene meq was deleted. Vaccine efficacy experiments conducted in Avian Disease and Oncology Laboratory (ADOL) 15I(5) x 7(1) chickens vaccinated with rMd5 Delta Meq virus or an ADOL preparation of CVI988/Rispens indicated that rMd5 Delta Meq provided superior protection than CVI988/Rispens when challenged with the very virulent plus MDV 648A strain. In the present study we set to investigate the vaccine efficacy of rMd5 Delta Meq in the field compared to several commercial preparations of CVI988/Rispens. Three large-scale field experiments, in which seeder chickens were inoculated with a very virulent plus strain of 686, vv+ MDV, were conducted in a model developed by Hy-Line International. In addition, comparisons were made with bivalent vaccine (HVT+SB-1), HVT alone and several serotype 3 HVT-vectored vaccines individually or in combination with CVI988/Rispens. Experimental results showed that addition of HVT to either of the two commercial CVI988/Rispens preparations tested (A or B) did not enhance protection conferred by CVI988/Rispens alo...Continue Reading

References

May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D JonesJ K Tillotson
Jul 29, 1967·Nature·A E Churchill, P M Biggs
Jan 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·K NazerianB R Burmester
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·L F LeeR L Witter
Aug 10, 2000·Journal of Virology·E R TulmanG F Kutish
May 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sanjay M ReddyRichard L Witter
Aug 4, 2004·Proceedings of the National Academy of Sciences of the United States of America·Blanca LupianiSanjay M Reddy
Sep 30, 2005·Avian Pathology : Journal of the W.V.P.A·R L WitterK A Schat
Oct 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Alon M LevyHsing-Jien Kung
Apr 1, 1979·Avian Pathology : Journal of the W.V.P.A·R L Witter, B R Burmester
Jan 1, 1975·Avian Pathology : Journal of the W.V.P.A·V V Bulow, P M Biggs

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Citations

Aug 2, 2013·Avian Diseases·Venugopal Nair
Nov 24, 2011·Avian Pathology : Journal of the W.V.P.A·Isabel M GimenoWillie M Reed
Aug 1, 2012·Avian Pathology : Journal of the W.V.P.A·Isabel M GimenoArun R Pandiri
May 31, 2013·Avian Pathology : Journal of the W.V.P.A·Mauricio J C CoppoJoanne M Devlin
Oct 20, 2018·Avian Diseases·I M Gimeno, K A Schat

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