Comparative evolution of Alzheimer disease, vascular dementia, and mixed dementia

Archives of Neurology
J V BowlerV Hachinski

Abstract

To compare the evolution of Alzheimer disease (AD), vascular dementia (VaD), and mixed dementia by cognitive domain. The University of Western Ontario Dementia Study, which is a registry of cases of dementia seen for secondary and tertiary assessment in a university memory disorders clinica with extensive follow-up data and histopathological confirmation of clinical diagnoses. One hundred twenty-nine patients with definite or probable AD, 12 patients with definite or probable VaD, and 36 patients with definite or probable mixed dementia. Patients were grouped as having an early, moderate, or advanced stage of disease according to the extended scale for dementia (ESD). The ESD was subdivided into cognitive domains, and the domain scores were compared for each stage of disease by diagnostic category with the use of a 2-way analysis of variance with repeated measures. As expected, the scores in all domains decreased significantly with increasing severity. There was a significant difference in the decline in memory among the diagnostic groups (P = .02) that was mostly attributable to the difference between AD and mixed dementia (P = .03), with the difference between AD and VaD only approaching significance (P = .06). There was a si...Continue Reading

Citations

Nov 6, 1998·Lancet·J van Gijn, M S Dennis
Jan 22, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·J V BowlerV Hachinski
Mar 27, 2004·Metabolism: Clinical and Experimental·Takuya WatanabeTakashi Katagiri
Aug 8, 2002·Journal of the American Geriatrics Society·Dina ZekryGabriel Gold
Nov 7, 2006·International Review of Psychiatry·Chiadi U Onyike
May 25, 2010·Journal of Communication Disorders·Jamie ReillyJean Neils-Strunjas
Mar 29, 2005·Journal of the Neurological Sciences·Teodoro Del SerDavid G Munoz
Aug 28, 2013·Journal of the Neurological Sciences·YanHong DongChristopher Chen
Nov 10, 2009·Immunity & Ageing : I & a·Francesco IemoloCalogero Caruso
Apr 19, 2016·Applied Neuropsychology. Adult·Cátia GonçalvesJosé M Santos
Aug 2, 2003·Applied Neuropsychology·Robert PaulRonald Cohen
Sep 30, 2005·Dementia and Geriatric Cognitive Disorders·Gustavo C RománRachel J Schindler
Dec 14, 2002·Annals of the New York Academy of Sciences·J C de la Torre
Apr 6, 2001·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·J JeongS H Han
Nov 1, 2002·International Clinical Psychopharmacology·G WilcockUNKNOWN MMM 500 group
Sep 14, 2001·Psychiatry and Clinical Neurosciences·Y KitabayashiK Fukui
Sep 7, 2002·Stroke; a Journal of Cerebral Circulation·Donald R Royall
Sep 8, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R J Schindler
May 20, 2000·Annals of the New York Academy of Sciences·K RockwoodP Montgomery
Jan 23, 2018·Dementia & Neuropsychologia·Nilton CustodioLucía Valeriano-Lorenzo
Feb 7, 2004·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Robert H PaulKelly Garrett
Jun 13, 2000·Alzheimer Disease and Associated Disorders·E VuorinenJ Rinne
May 15, 2019·Journal of Clinical Medicine·Karan GovindpaniAndrea Kwakowsky
Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·J C de la Torre
Jul 7, 2021·Revista colombiana de psiquiatría·Alberto J Mimenza-AlvaradoSara G Aguilar-Navarro

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.