PMID: 7939388Jan 1, 1994Paper

Comparative findings on serum IMg2+ of normal and diseased human subjects with the NOVA and KONE ISE's for Mg2+

Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
B M AlturaB T Altura


It is clear now that although different ionophores for ionized Mg (IMg2+) have been designed by several groups, each of these has a distinctly different KMgCa. In view of this, it is important to determine whether each of these ion selective electrodes (ISE's) yield identical results for IMg2+ in sera from healthy and diseased humans. Using such an approach, we determined, in a blinded-and random manner, IMg2+ with both the NOVA and KONE ISE's for IMg2+ in two independent laboratories. No significant differences were found either for sera from healthy human volunteers or diseased patients. We did, however, note several interesting findings: 1. randomly, selected hospitalized patients exhibit a much higher incidence of abnormalities for IMg2+ (57-71%) than that noted previously for total Mg (TMg) measurements; and 2. coronary heart disease, rectal cancer and multiple sclerosis patients exhibit extracellular deficits in ionized free Mg.


Mar 1, 1990·Acta Neurologica Scandinavica·M YasuiK Ohsugi
Mar 20, 1987·The American Journal of Medicine·R Whang
Jan 1, 1994·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·B T AlturaB M Altura

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