PMID: 7939388Jan 1, 1994Paper

Comparative findings on serum IMg2+ of normal and diseased human subjects with the NOVA and KONE ISE's for Mg2+

Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
B M AlturaB T Altura

Abstract

It is clear now that although different ionophores for ionized Mg (IMg2+) have been designed by several groups, each of these has a distinctly different KMgCa. In view of this, it is important to determine whether each of these ion selective electrodes (ISE's) yield identical results for IMg2+ in sera from healthy and diseased humans. Using such an approach, we determined, in a blinded-and random manner, IMg2+ with both the NOVA and KONE ISE's for IMg2+ in two independent laboratories. No significant differences were found either for sera from healthy human volunteers or diseased patients. We did, however, note several interesting findings: 1. randomly, selected hospitalized patients exhibit a much higher incidence of abnormalities for IMg2+ (57-71%) than that noted previously for total Mg (TMg) measurements; and 2. coronary heart disease, rectal cancer and multiple sclerosis patients exhibit extracellular deficits in ionized free Mg.

References

Mar 1, 1990·Acta Neurologica Scandinavica·M YasuiK Ohsugi
Mar 20, 1987·The American Journal of Medicine·R Whang
Jan 1, 1994·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·B T AlturaB M Altura

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Citations

Jun 16, 1999·Clinical Chemistry and Laboratory Medicine : CCLM·H J HuijgenR J Elin
Oct 21, 2004·American Journal of Hematology·Shahriar ZehtabchiBurton M Altura
Apr 25, 2007·Scandinavian Journal of Clinical and Laboratory Investigation·R SinertB M Altura
Dec 1, 1995·Scandinavian Journal of Clinical and Laboratory Investigation·Z I MemonB M Altura
May 15, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Frank H BoguschewskiJens P Heidrich
Jun 1, 1995·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·H IsingA Jeremias
Nov 6, 1998·Clinical Chemistry and Laboratory Medicine : CCLM·H SahaA Pasternack
Feb 1, 1997·Journal of the American College of Nutrition·M Seelig, B M Altura
May 15, 1998·Acta Paediatrica Japonica; Overseas Edition·K HoshinoR Uehara
Jan 1, 1996·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·B M Altura, B T Altura
May 20, 1998·Pediatric Neurology·J C MarcusB M Altura
Mar 23, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·N E SarisA Lewenstam

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