Comparative genome and transcriptome analyses of the social amoeba Acytostelium subglobosum that accomplishes multicellular development without germ-soma differentiation

BMC Genomics
H UrushiharaAsao Fujiyama

Abstract

Social amoebae are lower eukaryotes that inhabit the soil. They are characterized by the construction of a starvation-induced multicellular fruiting body with a spore ball and supportive stalk. In most species, the stalk is filled with motile stalk cells, as represented by the model organism Dictyostelium discoideum, whose developmental mechanisms have been well characterized. However, in the genus Acytostelium, the stalk is acellular and all aggregated cells become spores. Phylogenetic analyses have shown that it is not an ancestral genus but has lost the ability to undergo cell differentiation. We performed genome and transcriptome analyses of Acytostelium subglobosum and compared our findings to other available dictyostelid genome data. Although A. subglobosum adopts a qualitatively different developmental program from other dictyostelids, its gene repertoire was largely conserved. Yet, families of polyketide synthase and extracellular matrix proteins have not expanded and a serine protease and ABC transporter B family gene, tagA, and a few other developmental genes are missing in the A. subglobosum lineage. Temporal gene expression patterns are astonishingly dissimilar from those of D. discoideum, and only a limited fractio...Continue Reading

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Citations

Jan 27, 2016·Seminars in Cell & Developmental Biology·Gareth Bloomfield
Aug 19, 2015·Journal of Molecular Biology·Qingyou DuPauline Schaap
Jun 7, 2015·Molecular Phylogenetics and Evolution·Sanea SheikhSandra L Baldauf
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Oct 11, 2019·PLoS Biology·Cathleen M GreenMarlene Belfort
Jan 30, 2018·Genome Biology and Evolution·Falk HillmannGernot Glöckner

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Datasets Mentioned

BETA
PRJDG1513

Methods Mentioned

BETA
flow cytometry
whole genome shotgun sequencing
size

Software Mentioned

PCAP
ABySS
dicodon
CAP3
exonerate
Orange
Platanus
OrthoMCL

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