Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites

Malaria Journal
Patrath PonsuwannaThanat Chookajorn

Abstract

Malaria parasites have evolved a series of intricate mechanisms to survive and propagate within host red blood cells. Intra-erythrocytic parasitism requires these organisms to digest haemoglobin and detoxify iron-bound haem. These tasks are executed by haemoglobin-specific proteases and haem biocrystallization factors that are components of a large multi-subunit complex. Since haemoglobin processing machineries are functionally and genetically linked to the modes of action and resistance mechanisms of several anti-malarial drugs, an understanding of their evolutionary history is important for drug development and drug resistance prevention. Maximum likelihood trees of genetic repertoires encoding haemoglobin processing machineries within Plasmodium species, and with the representatives of Apicomplexan species with various host tropisms, were created. Genetic variants were mapped onto existing three-dimensional structures. Genome-wide single nucleotide polymorphism data were used to analyse the selective pressure and the effect of these mutations at the structural level. Recent expansions in the falcipain and plasmepsin repertoires are unique to human malaria parasites especially in the Plasmodium falciparum and P. reichenowi li...Continue Reading

References

Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·A A Escalante, F J Ayala
Sep 17, 1996·Proceedings of the National Academy of Sciences of the United States of America·A M SilvaJ W Erickson
Jan 1, 1997·Annual Review of Microbiology·S E FrancisD E Goldberg
Jul 18, 2002·Journal of Inorganic Biochemistry·Timothy J Egan
Jan 31, 2003·Proteins·Simon C LovellDavid C Richardson
Apr 8, 2003·Molecular Biology and Evolution·Kaare M NielsenDaniel L Hartl
Jul 24, 2003·The Journal of Biological Chemistry·Christina E Murata, Daniel E Goldberg
Jan 14, 2005·Bioinformatics·Federico AbascalDavid Posada
Jun 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kailash C PandeyPhilip J Rosenthal
Jul 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stephanie X WangJames H McKerrow
Nov 1, 2006·Molecular Microbiology·Marisa PonpuakDaniel E Goldberg
Jun 22, 2007·Molecular Microbiology·J Alfredo BonillaJohn B Dame
Feb 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·David A ElliottKeith A Joiner
Apr 26, 2008·PLoS Pathogens·Dewal JaniDharmendar Rathore
Sep 6, 2008·Trends in Parasitology·Thanat ChookajornLiwang Cui
Sep 17, 2008·Current Protocols in Bioinformatics·Julie D ThompsonDes G Higgins
Nov 14, 2008·Chemical Reviews·Isabelle Weissbuch, Leslie Leiserowitz
Jan 13, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Sumiti VinayakVenkatachalam Udhayakumar
Mar 17, 2009·Journal of Molecular Biology·Prasenjit BhaumikAlexander Wlodawer
Oct 23, 2010·PLoS Neglected Tropical Diseases·Byoung-Kuk NaYoon Kong
Dec 18, 2010·Protoplasma·Geoffrey Ian McFadden
Jun 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Nectarios KlonisLeann Tilley
Jun 30, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sergey KapishnikovMichael Elbaum
Jul 12, 2012·Systematic Biology·Daniel H Huson, Celine Scornavacca
Aug 31, 2012·Nature Genetics·Neil Hall
Feb 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Nectarios KlonisLeann Tilley
Mar 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Monika ChughPawan Malhotra
Apr 30, 2013·Nature Genetics·Olivo MiottoDominic P Kwiatkowski
May 15, 2013·Nucleic Acids Research·Hamish McWilliamRodrigo Lopez
Aug 21, 2013·Lancet·Nicholas J WhiteArjen M Dondorp
Dec 20, 2013·Nature·Frédéric ArieyDidier Ménard
Feb 22, 2014·Biochimica Et Biophysica Acta·Lorena M CoronadoCarmenza Spadafora
Mar 26, 2014·Antimicrobial Agents and Chemotherapy·Kesinee ChotivanichNicholas J White
Apr 18, 2014·Molecular Biology and Evolution·Krittikorn KümpornsinThanat Chookajorn
May 2, 2014·Nucleic Acids Research·Marco BiasiniTorsten Schwede
Jul 31, 2014·The New England Journal of Medicine·Elizabeth A AshleyUNKNOWN Tracking Resistance to Artemisinin Collaboration (TRAC)
Jan 20, 2015·Nature Genetics·Olivo MiottoDominic P Kwiatkowski

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
gene knock-out

Software Mentioned

ClustalX
RAMPAGE
GROMACS
MODEL
Dendroscope
RAxML
BLASTp
ProtTest
BLAST
SWISS

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antibody Repertoire Diversity

Antibody repertoire diversity and its role during natural infection is a prerequisite for molecular and structural elucidation of functionally protective immunity. Discover the latest insights into antibody diversity here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.