Comparative Genomic Analysis Reveals Genetic Mechanisms of the Variety of Pathogenicity, Antibiotic Resistance, and Environmental Adaptation of Providencia Genus

Frontiers in Microbiology
Chao YuanHong Chen

Abstract

The bacterial genus Providencia is Gram-negative opportunistic pathogens, which have been isolated from a variety of environments and organisms, ranging from humans to animals. Providencia alcalifaciens, Providencia rettgeri, and Providencia stuartii are the most common clinical isolates, however, these three species differ in their pathogenicity, antibiotic resistance and environmental adaptation. Genomes of 91 isolates of the genus Providencia were investigated to clarify their genetic diversity, focusing on virulence factors, antibiotic resistance genes, and environmental adaptation genes. Our study revealed an open pan-genome for the genus Providencia containing 14,720 gene families. Species of the genus Providencia exhibited different functional constraints, with the core genes, accessory genes, and unique genes. A maximum-likelihood phylogeny reconstructed with concatenated single-copy core genes classified all Providencia isolates into 11 distant groups. Comprehensive and systematic comparative genomic analyses revealed that specific distributions of virulence genes, which were highly homologous to virulence genes of the genus Proteus, contributed to diversity in pathogenicity of Providencia alcalifaciens, Providencia re...Continue Reading

References

Dec 1, 1992·Infection and Immunity·M J AlbertJ Montanaro
Mar 1, 1995·Journal of Medical Microbiology·M J AlbertA S Faruque
Nov 1, 1996·Memórias do Instituto Oswaldo Cruz·V MagalhãesM Magalhães
Feb 24, 2001·Journal of Medical Microbiology·M SobreiraA M Almeida
Sep 28, 2001·The Journal of Infectious Diseases·T MurataT Honda
Oct 16, 2001·Antimicrobial Agents and Chemotherapy·B HochhutM K Waldor
Dec 23, 2003·The Journal of Antimicrobial Chemotherapy·Mario TumbarelloRoberto Cauda
Sep 30, 2005·Journal of Medical Microbiology·Myonsun YohTakeshi Honda
Mar 4, 2006·International Journal of Systematic and Evolutionary Microbiology·Vishal S SomvanshiErko Stackebrandt
Oct 6, 2006·Molecular Microbiology·Anastasias EconomouAnthony P Pugsley
Aug 24, 2007·FEMS Immunology and Medical Microbiology·Sérgio P D RochaJacinta S Pelayo
Mar 20, 2008·Genome Research·Daniel R Zerbino, Ewan Birney
Apr 24, 2008·Molecular Microbiology·Praveen Alamuri, Harry L T Mobley
May 20, 2008·Journal of Bacteriology·Michael GillingsH W Stokes
Dec 18, 2008·Current Opinion in Microbiology·Hervé TettelinDuccio Medini
Mar 21, 2009·PLoS Genetics·J Christian PerezEduardo A Groisman
May 2, 2009·International Journal of Systematic and Evolutionary Microbiology·Punita Juneja, Brian P Lazzaro
Oct 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Michael Richter, Ramon Rosselló-Móra
Jul 17, 2010·Microbiology·Francesca BottaciniMarco Ventura
Oct 7, 2010·Molecular Microbiology·Stephanie D HimpslHarry L T Mobley
Jan 19, 2012·FEMS Microbiology Reviews·Ross E Dalbey, Andreas Kuhn
Aug 4, 2012·Molecular Microbiology·Eun-Jin Lee, Eduardo A Groisman
Sep 15, 2012·Molecular Biology and Evolution·Julien GuglielminiEduardo P C Rocha
Jan 19, 2013·Molecular Biology and Evolution·Kazutaka Katoh, Daron M Standley
Feb 15, 2013·Molecular Biology and Evolution·Lu ChengJukka Corander
Apr 2, 2013·Research in Microbiology·Sarah J Coulthurst
Jul 19, 2013·The Journal of General and Applied Microbiology·Suwannee KhunthongpanAran H-Kittikun
Jan 1, 2014·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Sihem MahroukiOmrane Belhadj
Apr 1, 2014·Biochimica Et Biophysica Acta·Abdelrahim ZouedEric Cascales
May 23, 2014·Microbiology and Molecular Biology Reviews : MMBR·Michael R Gillings
Jul 30, 2014·Cell Host & Microbe·Alistair B RussellJoseph D Mougous
Feb 3, 2015·Environmental Microbiology·Jun LiHong-Yu Ou
Feb 13, 2015·PLoS Computational Biology·Xavier Didelot, Daniel J Wilson
Mar 11, 2015·Diagnostic Microbiology and Infectious Disease·Panagiota GiakkoupiAlkiviadis Vatopoulos

❮ Previous
Next ❯

Citations

Jun 11, 2021·Diagnostic Microbiology and Infectious Disease·Isabella A TicklerFred C Tenover
Aug 28, 2021·Microorganisms·David Lupande-MwenebituSeydina M Diene

❮ Previous
Next ❯

Datasets Mentioned

BETA
PRJNA580371

Methods Mentioned

BETA
ICEs
phosphotransferase

Software Mentioned

MEGA
IslandViewer
Bayesian Analysis of Population Structure ( BAPS )
R
MacSyFinder
PHAge Search Tool Enhanced Release ( PHASTER )
- BSR
MAFFT
Velvet Optimiser
pheatmap

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Ceskoslovenská epidemiologie, mikrobiologie, imunologie
V BYDZOVSKY, J DUDEK
Annales de l'Institut Pasteur de Lille
R BUTTIAUXJ MORIAMEZ
Zhurnal mikrobiologii, epidemiologii, i immunobiologii
E V Kholodkova, V P Raginskaia
© 2021 Meta ULC. All rights reserved