Comparative genomic and phylogenetic investigation of the xenobiotic metabolizing arylamine N-acetyltransferase enzyme family

FEBS Letters
Anthony E GlennSotiria Boukouvala

Abstract

Arylamine N-acetyltransferases (NATs) are xenobiotic metabolizing enzymes characterized in several bacteria and eukaryotic organisms. We report a comprehensive phylogenetic analysis employing an exhaustive dataset of NAT-homologous sequences recovered through inspection of 2445 genomes. We describe the first NAT homologues in viruses, archaea, protists, many fungi and invertebrates, providing complete annotations in line with the consensus nomenclature. Contrary to the NAT genes of vertebrates, introns are commonly found within the homologous coding regions of lower eukaryotes. The NATs of fungi and higher animals are distinctly monophyletic, but evidence supports a mixed phylogeny of NATs among bacteria, protists and possibly some invertebrates.

References

Aug 13, 2003·Bioinformatics·Fredrik Ronquist, John P Huelsenbeck
Oct 16, 2004·Science·Didier RaoultJean-Michel Claverie
Nov 1, 2005·Drug Metabolism Reviews·Sotiria Boukouvala, Giannoulis Fakis
Nov 30, 2005·Nucleic Acids Research·Alexandre LomsadzeMark Borodovsky
Aug 24, 2006·Genome Biology·Victor SolovyevDenis Vorobyev
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Feb 29, 2008·BMC Genetics·Audrey SabbaghEstella S Poloni
Mar 13, 2008·Pharmacogenetics and Genomics·David W HeinEdith Sim
Jun 4, 2008·Pharmacogenomics·Sotiria BoukouvalaGiannoulis Fakis
Jul 22, 2008·Drug Metabolism Reviews·Edith SimSotiria Boukouvala
Sep 6, 2008·PloS One·Francesca LucaAndrea Novelletto
Sep 11, 2008·Current Drug Metabolism·Eirini VagenaSotiria Boukouvala
Apr 21, 2009·Methods in Molecular Biology·Enrique Blanco, Josep F Abril
May 7, 2009·The Journal of Biological Chemistry·Marta MartinsJean-Marie Dupret
Jun 12, 2009·Journal of Virology·David C LambSteven L Kelly
Nov 17, 2009·Trends in Plant Science·Ralph Bock

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Citations

Jan 8, 2013·Expert Opinion on Drug Metabolism & Toxicology·Xavier KubiakFernando Rodrigues-Lima
Mar 14, 2013·Journal of Chemical Ecology·Jennifer Sorensen ForbeyWilliam J Foley
Feb 3, 2012·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Xavier KubiakFernando Rodrigues-Lima
May 2, 2012·The Biochemical Journal·Xavier KubiakFernando Rodrigues-Lima
Nov 2, 2019·World Journal of Microbiology & Biotechnology·Vasiliki GarefalakiSotiria Boukouvala
Feb 5, 2021·Frontiers in Microbiology·Xinning LiuXiming Xu
Jul 22, 2021·Applied and Environmental Microbiology·Vasiliki GarefalakiSotiria Boukouvala

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