Abstract
Arylamine N-acetyltransferases (NATs) are xenobiotic metabolizing enzymes characterized in several bacteria and eukaryotic organisms. We report a comprehensive phylogenetic analysis employing an exhaustive dataset of NAT-homologous sequences recovered through inspection of 2445 genomes. We describe the first NAT homologues in viruses, archaea, protists, many fungi and invertebrates, providing complete annotations in line with the consensus nomenclature. Contrary to the NAT genes of vertebrates, introns are commonly found within the homologous coding regions of lower eukaryotes. The NATs of fungi and higher animals are distinctly monophyletic, but evidence supports a mixed phylogeny of NATs among bacteria, protists and possibly some invertebrates.
References
Feb 28, 1998·Nucleic Acids Research·J D ThompsonD G Higgins
Aug 13, 2003·Bioinformatics·Fredrik Ronquist, John P Huelsenbeck
Oct 16, 2004·Science·Didier RaoultJean-Michel Claverie
Nov 1, 2005·Drug Metabolism Reviews·Sotiria Boukouvala, Giannoulis Fakis
Nov 30, 2005·Nucleic Acids Research·Alexandre LomsadzeMark Borodovsky
Aug 24, 2006·Genome Biology·Victor SolovyevDenis Vorobyev
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Sep 1, 2007·Science·Julie C Dunning HotoppJohn H Werren
Feb 15, 2008·Nature·Nicole KingDaniel Rokhsar
Feb 29, 2008·BMC Genetics·Audrey SabbaghEstella S Poloni
Mar 13, 2008·Pharmacogenetics and Genomics·David W HeinEdith Sim
Jun 4, 2008·Pharmacogenomics·Sotiria BoukouvalaGiannoulis Fakis
Jul 22, 2008·Drug Metabolism Reviews·Edith SimSotiria Boukouvala
Sep 6, 2008·PloS One·Francesca LucaAndrea Novelletto
Sep 11, 2008·Current Drug Metabolism·Eirini VagenaSotiria Boukouvala
Mar 24, 2009·Journal of Applied Microbiology·A E Glenn, C W Bacon
Apr 21, 2009·Methods in Molecular Biology·Enrique Blanco, Josep F Abril
Apr 22, 2009·Expert Opinion on Drug Metabolism & Toxicology·David W Hein
May 7, 2009·The Journal of Biological Chemistry·Marta MartinsJean-Marie Dupret
Jun 12, 2009·Journal of Virology·David C LambSteven L Kelly
Nov 17, 2009·Trends in Plant Science·Ralph Bock
Citations
Mar 19, 2013·BMC Evolutionary Biology·Audrey SabbaghBrigitte Crouau-Roy
Dec 18, 2013·Gene·Theodora TsirkaGiannoulis Fakis
Jan 8, 2013·Expert Opinion on Drug Metabolism & Toxicology·Xavier KubiakFernando Rodrigues-Lima
Aug 8, 2015·Scientific Reports·Eleni P KaragianniSotiria Boukouvala
Jan 26, 2016·PloS One·Anthony E GlennMaurice E Snook
Mar 14, 2013·Journal of Chemical Ecology·Jennifer Sorensen ForbeyWilliam J Foley
Feb 3, 2012·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Xavier KubiakFernando Rodrigues-Lima
Jul 13, 2019·PloS One·Thomas BaldwinJuliet Marshall
May 2, 2012·The Biochemical Journal·Xavier KubiakFernando Rodrigues-Lima
Feb 11, 2015·Acta Crystallographica. Section D, Biological Crystallography·Ximing XuFernando Rodrigues-Lima
Jan 1, 2014·SpringerPlus·Bapi GorainTuhinadri Sen
Nov 2, 2019·World Journal of Microbiology & Biotechnology·Vasiliki GarefalakiSotiria Boukouvala
Oct 19, 2017·Scientific Reports·Daniel R DempseyDavid J Merkler
Jun 19, 2013·The Journal of Biological Chemistry·Xavier KubiakFernando Rodrigues-Lima
Jun 29, 2018·Scientific Reports·Theodora TsirkaGiannoulis Fakis
Feb 5, 2021·Frontiers in Microbiology·Xinning LiuXiming Xu
Feb 25, 2020·Biochemical and Biophysical Research Communications·Ximing XuFernando Rodrigues-Lima
Jul 22, 2021·Applied and Environmental Microbiology·Vasiliki GarefalakiSotiria Boukouvala