Comparative genomic and proteomic analyses of two Mycoplasma agalactiae strains: clues to the macro- and micro-events that are shaping mycoplasma diversity.

BMC Genomics
Laurent X NouvelChristine Citti

Abstract

While the genomic era is accumulating a tremendous amount of data, the question of how genomics can describe a bacterial species remains to be fully addressed. The recent sequencing of the genome of the Mycoplasma agalactiae type strain has challenged our general view on mycoplasmas by suggesting that these simple bacteria are able to exchange significant amount of genetic material via horizontal gene transfer. Yet, events that are shaping mycoplasma genomes and that are underlining diversity within this species have to be fully evaluated. For this purpose, we compared two strains that are representative of the genetic spectrum encountered in this species: the type strain PG2 which genome is already available and a field strain, 5632, which was fully sequenced and annotated in this study. The two genomes differ by ca. 130 kbp with that of 5632 being the largest (1006 kbp). The make up of this additional genetic material mainly corresponds (i) to mobile genetic elements and (ii) to expanded repertoire of gene families that encode putative surface proteins and display features of highly-variable systems. More specifically, three entire copies of a previously described integrative conjugative element are found in 5632 that account...Continue Reading

References

Oct 20, 1995·Science·C M FraserJ C Venter
May 1, 1996·Veterinary Microbiology·M SolsonaF Poumarat
Sep 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·J Mahillon, M Chandler
Dec 20, 2000·Bioinformatics·K RutherfordB Barrell
May 23, 2001·Nucleic Acids Research·I ChambaudA Blanchard
Oct 6, 2001·Current Opinion in Microbiology·U Dobrindt, J Hacker
Jan 25, 2002·Journal of Bacteriology·Amy M TeachmanKevin Dybvig
Sep 14, 2002·Infection and Immunity·Bénédicte FleuryEdy M Vilei
Oct 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Mark A SchellFabrizio Arigoni
Nov 8, 2002·Molecular Microbiology·Ramakrishnan SitaramanKevin Dybvig
Dec 19, 2002·Veterinary Microbiology·Paola PiloEdy M Vilei
Feb 21, 2003·Avian Pathology : Journal of the W.V.P.A·Dusan Bencina
Dec 19, 2003·Nucleic Acids Research·Aurélien BarréAlain Blanchard
Jan 6, 2004·Nucleic Acids Research·Dean Laslett, Bjorn Canback
Jun 25, 2004·Nucleic Acids Research·Kelly A FrazerInna Dubchak
Oct 19, 2004·Journal of Bacteriology·F Chris MinionGregory G Mahairas
Jun 25, 2005·Bioinformatics·Tim J CarverJulian Parkhill
Sep 3, 2005·Nature Reviews. Microbiology·Christopher M Thomas, Kaare M Nielsen
Sep 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hervé TettelinClaire M Fraser
Sep 28, 2005·Current Opinion in Genetics & Development·Duccio MediniRino Rappuoli
Mar 4, 2006·Science·Francesca D CiccarelliPeer Bork
Nov 28, 2006·International Journal of Medical Microbiology : IJMM·Gerhard HeusippM Alexander Schmidt
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
May 22, 2007·PLoS Genetics·Pascal Sirand-PugnetChristine Citti
Jun 30, 2007·Science·Carole LartigueJ Craig Venter
Nov 21, 2007·Research in Microbiology·Pascal Sirand-PugnetAlain Blanchard
Feb 6, 2008·Molecular Microbiology·Rohini Chopra-DewasthalyWolfgang Jechlinger
Jun 25, 2008·Infection and Immunity·Kevin DybvigAnn E Loraine
Sep 3, 2008·Molecular Microbiology·Gordon Churchward
Sep 30, 2008·Trends in Microbiology·David E Whitworth
Nov 8, 2008·Bioinformatics·Tim CarverJulian Parkhill

❮ Previous
Next ❯

Citations

Sep 17, 2013·Systematic and Applied Microbiology·Giuseppe FirraoSabrina Palmano
Dec 8, 2010·Infection and Immunity·Kim S WiseBarbara A Methé
Feb 4, 2010·Infection and Immunity·Eric BaranowskiChristine Citti
Mar 15, 2011·Journal of Bacteriology·Joern OehlerkingLudwig E Hoelzle
Sep 2, 2010·Microbiology and Molecular Biology Reviews : MMBR·Chris SmillieFernando de la Cruz
Feb 18, 2011·BMC Genomics·Francois ThiaucourtPascal Sirand-Pugnet
Jun 12, 2012·PloS One·Laure BévenPascal Sirand-Pugnet
Jul 17, 2010·Future Microbiology·Christine CittiEric Baranowski
Apr 12, 2016·Mobile Genetic Elements·Mizue Naito, Teresa E Pawlowska
Feb 20, 2013·Trends in Microbiology·Christine Citti, Alain Blanchard
May 16, 2012·Comparative Immunology, Microbiology and Infectious Diseases·Laurent-Xavier NouvelChristine Citti
Jun 21, 2011·Veterinary Microbiology·G F BrowningP F Markham
Mar 5, 2011·Journal of Medical Microbiology·L McAuliffeR J Ellis
Nov 27, 2010·Microbiology·Hagai RechnitzerShlomo Rottem
Jan 17, 2015·Cell Calcium·Ian R BoothLaura Lehtovirta-Morley
Nov 27, 2014·MBio·Emilie Dordet-FrisoniChristine Citti
Oct 23, 2014·PloS One·Jennifer M FettweisGregory A Buck
May 12, 2016·Cellular Microbiology·Carla CacciottoAlberto Alberti
Jul 23, 2015·Database : the Journal of Biological Databases and Curation·Rian PierneefOleg N Reva
Dec 21, 2014·Applied and Environmental Microbiology·Florence TardyChristine Citti
Aug 21, 2016·Applied and Environmental Microbiology·Eytan AmramInna Lysnyansky
Feb 23, 2017·Frontiers in Cellular and Infection Microbiology·Tjerko KammingaPeter J Schaap
Nov 12, 2019·Frontiers in Microbiology·Emilie Dordet-FrisoniChristine Citti
Jul 28, 2020·Genes·Christine CittiLaurent-Xavier Nouvel
Dec 12, 2019·Frontiers in Microbiology·Thomas IpoutchaPascal Sirand-Pugnet

❮ Previous
Next ❯

Datasets Mentioned

BETA
CU179680
FP671138
ABI3730

Methods Mentioned

BETA
restriction modification
ICE
ICEs

Software Mentioned

ACT
Artemis Comparison Tool ( ACT )
ARAGORN
SE
tRNAscan
MEGA
MAST
mVISTA
VISTA
Artemis

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.