PMID: 7519052Apr 1, 1994Paper

Comparative genomic hybridization as a tool to define two distinct chromosome 12-derived amplification units in well-differentiated liposarcomas

Genes, Chromosomes & Cancer
R F SuijkerbuijkA Geurts van Kessel

Abstract

Well-differentiated liposarcomas (WDLPS) are frequently characterized by a near-diploid karyotype with supernumerary ring and/or giant rod-shaped marker chromosomes. We have shown, using fluorescence in situ hybridization (FISH) and molecular strategies, that these markers contain chromosome 12-derived sequences. Here we report the analysis of six WDLPS for the presence of amplified DNA segments by means of the recently developed comparative genomic hybridization (CGH) strategy. Two distinct chromosome 12-derived amplification units could be identified in all tumors examined, one located in the q14-q15 region as expected, the second unexpectedly mapping to q21.3-q22. Our results indicate that the concerted amplification of these two distinct regions on the long arm of chromosome 12 may be a consistent characteristic of WDLPS. These amplifications are most likely directly related to the presence of supernumerary ring and/or giant marker chromosomes in this group of soft tissue tumors.

References

Jul 15, 1992·Cancer Genetics and Cytogenetics·I J Urumov, Y Manolova
Jan 1, 1992·Cytogenetics and Cell Genetics·I CraigR Kucherlapati
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Citations

Dec 1, 1996·Genes, Chromosomes & Cancer·J M BernerO Myklebost
Mar 1, 1995·Genes, Chromosomes & Cancer·M BentzP Lichter
Jul 15, 1995·Cancer Genetics and Cytogenetics·R SerucaM Sobrinho-Simões
Jun 20, 2002·Cancer Genetics and Cytogenetics·Stéphanie StruskiPascale Cornillet-Lefebvre
May 1, 1997·Cancer Genetics and Cytogenetics·A Geurts van KesselB de Leeuw
Jan 1, 1997·Cancer Genetics and Cytogenetics·N C Popescu, D B Zimonjic
Jan 15, 1998·Cancer Genetics and Cytogenetics·E P NachevaA R Green
Mar 24, 1999·Cancer Genetics and Cytogenetics·A Geurts van KesselR P Veth
Dec 22, 1999·Cancer Genetics and Cytogenetics·F ParenteC Turc-Carel
Sep 8, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Andrew E HorvaiFrederic Waldman
Nov 13, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hannelore SchmidtHelge Taubert
Apr 22, 2010·Cytogenetic and Genome Research·A DutraO A Olivero
Jan 1, 1996·Progress in Histochemistry and Cytochemistry·J C Alers, H van Dekken
Feb 22, 2005·Biochemical and Biophysical Research Communications·Kazunori KawaguchiShuichi Kaneko
Nov 6, 2004·Cancer Genetics and Cytogenetics·Avery A Sandberg
Jun 9, 2012·Virchows Archiv : an International Journal of Pathology·Florence PedeutourJean-Michel Coindre
Feb 1, 1997·Acta Orthopaedica Scandinavica. Supplementum·M Nilbert

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