Comparative genomic hybridization (CGH)-arrays pave the way for identification of novel cancer-related genes

Cancer Science
Johji InazawaIssei Imoto

Abstract

Comparative genomic hybridization (CGH) has already made a significant impact on cancer cytogenetics. However, CGH to metaphase chromosomes can provide only limited resolution at the 5-10 Mb level. To circumvent this limitation, array-based CGH has been devised. Since spotted DNAs in a CGH-array contain sequence information directly connected with the genome database, we can easily note particular biological aspects of genes that lie within regions involved in copy-number aberrations. High-density, sub-megabase arrays can reveal nonrandom chromosome copy-number aberrations responsible for neoplastic transformation that have been masked under complex karyotypes in epithelial solid tumors. High-density CGH-array therefore paves the way for identification of disease-related genetic aberrations that have not yet been detected by existing technologies, and array-based CGH technology should soon be practical for diagnosis of cancer or genetic diseases in the clinical setting.

References

Apr 1, 1997·Nature Genetics·F MitelmanB Johansson
Dec 31, 1997·Genes, Chromosomes & Cancer·S Solinas-ToldoP Lichter
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·C CollinsJ W Gray
Jan 23, 1999·Nature Genetics·L ShayestehJ W Gray
Feb 9, 1999·Human Molecular Genetics·T H HuangD E Laux
Feb 23, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K Barton, G Nucifora
Nov 1, 2001·Nature Genetics·A M SnijdersD G Albertson
Jul 11, 2002·The American Journal of Pathology·Sana YokoiJohji Inazawa
Aug 16, 2002·Journal of Human Genetics·Izuho HatadaKenichi Matsubara
Dec 4, 2002·Journal of Cellular Biochemistry·Huidong ShiTim Hui-Ming Huang
May 24, 2003·Leukemia·R Hehlmann
Jun 26, 2003·Cancer Science·Sana YokoiJohji Inazawa
Aug 14, 2003·Human Molecular Genetics·Donna G Albertson, Daniel Pinkel
Jan 30, 2004·Trends in Genetics : TIG·Kiran K MantripragadaJan P Dumanski
Feb 6, 2004·Genome Research·Graham R BignellRichard Wooster
Feb 26, 2004·Nature Genetics·Adrian S IshkanianWan L Lam
Feb 15, 2005·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Hubert S SwanaLaurence Baskin

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Citations

Sep 5, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Mandeep S TamberJames T Rutka
Nov 14, 2008·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Narasimharao V MarellaRonald Berezney
Mar 6, 2008·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Hitoshi Tsuda
Nov 17, 2005·European Journal of Human Genetics : EJHG·William W LockwoodWan L Lam
Jan 9, 2009·Bioinformatics·Jumamurat R BayjanovDouwe Molenaar
Feb 28, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Paulette Mhawech-FaucegliaKunle Odunsi
Aug 30, 2008·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Paulette Mhawech-FaucegliaTanja Pejovic
May 29, 2008·Blood·Jaroslaw P Maciejewski, Ghulam J Mufti
Nov 7, 2008·Endocrine-related Cancer·Robert C SmallridgeJohn A Copland
Oct 20, 2006·Critical Reviews in Clinical Laboratory Sciences·Qinghua FengNancy B Kiviat
Apr 16, 2011·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Siobhan C McKayDuncan R C Spalding
Jan 30, 2007·Experimental Hematology·Christine L O'KeefeJaroslaw P Maciejewski
Jul 10, 2009·International Journal of Cancer. Journal International Du Cancer·Yu NakamuraTatsuhiro Shibata
Jun 29, 2006·Annals of the New York Academy of Sciences·Tomasz K Wojdacz, Lise Lotte Hansen
Jul 2, 2009·International Journal of Cancer. Journal International Du Cancer·Eri AraiYae Kanai

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