Abstract
Nasal-type NK/T-cell lymphoma is a rare type of non-Hodgkin's lymphoma. The genetic changes associated with pathogenesis have not been well defined. This study investigates the nonrandom genetic alteration of nasal-type NK/T-cell lymphoma. Nine cases were studied. Comparative genomic hybridization (CGH) was carried out using fresh tumor tissues of seven nasal-type NK/T-cell lymphomas. To complement the data by CGH, loss of heterozygosity (LOH) of chromosomes 6q, 1p, and 17p using polymorphic markers and p53 gene mutation by polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) were analyzed. The DNA copy number changes of seven nasal-type NK/T-cell lymphomas were gains on chromosomes 2q(5), 13q(4), 10q(3), 21q(2), 3q(2), 5q(2), and 17q(2), and losses involving chromosomes 1p(4), 17p(4), 12q(3), 13q(2), and 6q(1). One of six cases informative for at least two markers for chromosome 6q showed LOH at D6S300, D6S1639, D6S261, D6S407, and D6S292. Two cases showing loss of 1p and 17q by CGH revealed LOH at D1S214, D1S503, and D17S559. P53 mutation was detected in exon 8 in one of nine cases. Frequent DNA losses at 1p, 17p, and 12q and gains at 2q, 13q, and 10q suggested that these regions could be targets for f...Continue Reading
References
Nov 22, 1991·Science·R A Weinberg
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L R FingerC M Croce
Aug 1, 1994·Genes, Chromosomes & Cancer·O P KallioniemiD Pinkel
Mar 1, 1995·The American Journal of Surgical Pathology·S NakamuraE Katoh
Jun 1, 1995·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·J BenhattarJ Costa
Jun 15, 1997·Genomics·I GantzT Yamada
Jun 1, 1997·British Journal of Haematology·H F TienS M Chuang
Sep 18, 1997·American Journal of Clinical Pathology·M ChhanabhaiD E Horsman
Nov 5, 1997·British Journal of Haematology·K F WongY L Kwong
Nov 14, 1997·Science·E R Fearon
Nov 14, 1997·International Journal of Cancer. Journal International Du Cancer·A K ChiangF C Ho
Jun 22, 1999·Leukemia·M A HoeveJ H van Krieken
Jul 22, 1999·Human Pathology·L Quintanilla-MartinezI T Magrath
Aug 10, 1999·Leukemia & Lymphoma·K F WongJ K Chan
Nov 7, 1999·The American Journal of Pathology·L L SiuY L Kwong
Apr 26, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·T LiK Aozasa
Jun 29, 2000·Human Pathology·N WongP J Johnson
Nov 7, 2000·Cancer·Y H KoS W Kim
Citations
Sep 18, 2012·Current Hematologic Malignancy Reports·Lindsay C GeorgeChristopher P Fox
Jun 19, 2013·Best Practice & Research. Clinical Haematology·Yenlin HuangPhilippe Gaulard
Apr 28, 2004·Leukemia Research·Maxim WanWing Chan
Apr 20, 2011·Leukemia·A WatanabeK Sawada
Jul 31, 2009·Blood·Yasuo YamanakaKen-ichi Sawada
Apr 21, 2010·Blood·Emilio BertiPamela Vezzoli
Jul 3, 2013·Orphanet Journal of Rare Diseases·Margarida Lima
Jun 24, 2014·Medical Oncology·Lin SunCuiling Liu
Feb 13, 2004·Leukemia & Lymphoma·Jiyoung Yoon, Young H Ko
Jan 18, 2014·Journal of the American Academy of Dermatology·Isabella FriedLorenzo Cerroni
May 9, 2012·Cancer Genetics·Silvia UccellaMaria Grazia Tibiletti
Aug 20, 2003·The Journal of Investigative Dermatology·Xin MaoSean Whittaker
Jun 21, 2007·American Journal of Clinical Pathology·Kathleen T Montone
Sep 24, 2004·Genes, Chromosomes & Cancer·Bárbara MeléndezJavier Benítez
Jul 29, 2005·Genes, Chromosomes & Cancer·Yasuhiro NakashimaMasao Seto
Aug 6, 2003·British Journal of Haematology·H Sunny SunSheen-Yie Fang
Dec 14, 2006·International Journal of Cancer. Journal International Du Cancer·Wei WuJianjun Chen
May 10, 2012·Cancer Science·Michela BoiFrancesco Bertoni
Jan 21, 2014·The Journal of Dermatology·Sanghui Park, Young H Ko
Jan 21, 2014·Journal of Experimental & Clinical Cancer Research : CR·Li LiangTing Li
May 5, 2011·Journal of Biomedicine & Biotechnology·Christian SchmittArmand Bensussan
Dec 20, 2005·Human Pathology·Ting LiHongfang Yin
Nov 26, 2005·Annals of Diagnostic Pathology·Francisco VegaL Jeffrey Medeiros
Nov 19, 2015·Médecine sciences : M/S·Lucile CouronnéOlivier Bernard
Dec 17, 2014·Immunological Reviews·Giorgio InghiramiUNKNOWN AIRC 5xMille consortium ‘Genetics-driven targeted management of lymphoid malignancies’
Jul 30, 2015·BioMed Research International·Li LiangTing Li
Jan 24, 2015·Blood·Yun-Wen ChenGopesh Srivastava
Dec 8, 2009·Blood·Yenlin HuangPhilippe Gaulard
Oct 6, 2016·Hematological Oncology·Zhang ZhangTing Li
Feb 6, 2009·Leukemia·J IqbalW C Chan
Nov 16, 2002·The Journal of Dermatology·Dong-Kyu HwangYong Wook Park
Dec 6, 2018·Journal of Hematology & Oncology·Jie Xiong, Wei-Li Zhao
May 30, 2019·Frontiers in Oncology·Qingqing CaiKen H Young
Jul 4, 2018·International Journal of Molecular Sciences·Sanjay de MelSiok-Bian Ng
May 6, 2004·Cancer Research·Akinobu OtaMasao Seto
Sep 6, 2020·Human Pathology·Juehua GaoYi-Hua Chen
Apr 4, 2021·Cancers·Ivonne A Montes-MojarroLeticia Quintanilla-Martinez