Comparative Genomics of Lactobacillus brevis Reveals a Significant Plasmidome Overlap of Brewery and Insect Isolates

Current Microbiology
Marion E FraunhoferRudi F Vogel


Lactobacillus (L.) brevis represents a versatile, ubiquitistic species of lactic acid bacteria, occurring in various foods, as well as plants and intestinal tracts. The ability to deal with considerably differing environmental conditions in the respective ecological niches implies a genomic adaptation to the particular requirements to use it as a habitat beyond a transient state. Given the isolation source, 24 L. brevis genomes were analyzed via comparative genomics to get a broad view of the genomic complexity and ecological versatility of this species. This analysis showed L. brevis being a genetically diverse species possessing a remarkably large pan genome. As anticipated, it proved difficult to draw a correlation between chromosomal settings and isolation source. However, on plasmidome level, brewery- and insect-derived strains grouped into distinct clusters, referable to a noteworthy gene sharing between both groups. The brewery-specific plasmidome is characterized by several genes, which support a life in the harsh environment beer, but 40% of the brewery plasmidome were found in insect-derived strains as well. This suggests a close interaction between these habitats. Further analysis revealed the presence of a truncated...Continue Reading


May 15, 2019·Microorganisms·Franca RossiGiampaolo Colavita
Aug 5, 2020·Applied Microbiology and Biotechnology·Se Hee LeeChe Ok Jeon
Nov 10, 2020·Microbial Genomics·Dimple DavrayRam Kulkarni


Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Dec 11, 1999·Nucleic Acids Research·Minoru Kanehisa, S Goto
Dec 11, 1999·Nucleic Acids Research·J QuackenbushJ Upton
Feb 18, 2003·Journal of Applied Microbiology·H AnnukM Mikelsaar
May 15, 2003·International Journal of Food Microbiology·J K MugulaT Sørhaug
Nov 19, 2003·International Journal of Food Microbiology·Kanta Sakamoto, Wil N Konings
Jun 25, 2004·Nucleic Acids Research·Aron Marchler-Bauer, Stephen H Bryant
Jul 3, 2004·Genome Research·Aaron E DarlingNicole T Perna
Dec 21, 2004·Nucleic Acids Research·Aron Marchler-BauerStephen H Bryant
Jun 28, 2005·International Journal of Food Microbiology·Susana SeseñaLlanos Palop
May 16, 2006·Journal of Applied Microbiology·K IijimaH Yamashita
Oct 6, 2006·Applied and Environmental Microbiology·Jürgen BehrRudi F Vogel
Nov 21, 2007·Methods in Molecular Biology·Aaron E DarlingNicole T Perna
Feb 12, 2008·BMC Genomics·Ramy K AzizOlga Zagnitko
May 15, 2008·Nucleic Acids Research·Shujiro OkudaMinoru Kanehisa
Mar 7, 2009·BMC Microbiology·Orla O'SullivanTom Beresford
Jun 23, 2009·Journal of Agricultural and Food Chemistry·Jürgen Behr, Rudi F Vogel
Oct 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Michael Richter, Ramon Rosselló-Móra
Nov 3, 2009·Applied and Environmental Microbiology·Jürgen Behr, Rudi F Vogel
Dec 17, 2009·BMC Bioinformatics·Christiam CamachoThomas L Madden
Jan 7, 2010·BMC Bioinformatics·Ben C Stöver, Kai F Müller
Apr 10, 2010·Journal of Food Protection·C L GerezG Font de Valdez
Jun 3, 2011·Environmental Microbiology·Chun Nin Adam WongAngela E Douglas
Oct 26, 2011·Microbial Cell Factories·Rudi F VogelWolfgang Liebl
Nov 12, 2013·Nucleic Acids Research·Minoru KanehisaMao Tanabe
Dec 3, 2013·Nucleic Acids Research·Ross OverbeekRick Stevens
Jan 15, 2014·Journal of Nutritional Science and Vitaminology·Yukio TakiiEmi Nagayoshi
Oct 15, 2014·Cell Reports·Joaquin F ChristiaensKevin J Verstrepen
Oct 30, 2014·Nucleic Acids Research·Damian SzklarczykChristian von Mering
Nov 10, 2015·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Attila KántorMiroslava Kačániová

Related Concepts

Lactic ACID bacteria
Lactobacillus brevis
Genomic Stability
Isolate compound

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.