Comparative genomics of molybdenum utilization in prokaryotes and eukaryotes

BMC Genomics
Ting PengYan Zhang

Abstract

Molybdenum (Mo) is an essential micronutrient for almost all biological systems, which holds key positions in several enzymes involved in carbon, nitrogen and sulfur metabolism. In general, this transition metal needs to be coordinated to a unique pterin, thus forming a prosthetic group named molybdenum cofactor (Moco) at the catalytic sites of molybdoenzymes. The biochemical functions of many molybdoenzymes have been characterized; however, comprehensive analyses of the evolution of Mo metabolism and molybdoproteomes are quite limited. In this study, we analyzed almost 5900 sequenced organisms to examine the occurrence of the Mo utilization trait at the levels of Mo transport system, Moco biosynthetic pathway and molybdoproteins in all three domains of life. A global map of Moco biosynthesis and molybdoproteins has been generated, which shows the most detailed understanding of Mo utilization in prokaryotes and eukaryotes so far. Our results revealed that most prokaryotes and all higher eukaryotes utilize Mo whereas many unicellular eukaryotes such as parasites and most yeasts lost the ability to use this metal. By characterizing the molybdoproteomes of all organisms, we found many new molybdoprotein-rich species, especially in...Continue Reading

References

Nov 5, 1997·Archives of Microbiology·A M Grunden, K T Shanmugam
Apr 9, 2001·The Journal of Biological Chemistry·K MakdessiA Pich
Apr 16, 2002·Biochemistry. Biokhimii︠a︡·N P L'vovA N Antipov
Jul 31, 2002·Journal of Experimental Botany·Ralf R Mendel, Robert Hänsch
May 4, 2006·Annual Review of Plant Biology·Günter Schwarz, Ralf R Mendel
Jul 29, 2006·The Journal of Biological Chemistry·Katrin FischerGuenter Schwarz
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Grazyna B SeiffertOliver Einsle
Nov 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hajime TomatsuToru Fujiwara
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Manuel Tejada-JiménezEmilio Fernández
Dec 22, 2007·Annals of the New York Academy of Sciences·Jan R Andreesen, Kathrin Makdessi
May 20, 2008·Journal of Molecular Biology·Yan Zhang, Vadim N Gladyshev
Aug 14, 2009·Nature·Günter SchwarzMarkus W Ribbe
Nov 6, 2009·The Journal of Biological Chemistry·Yan Zhang, Vadim N Gladyshev
Dec 31, 2009·The Journal of Biological Chemistry·Tobias KruseRalf R Mendel
Nov 27, 2010·Nucleic Acids Research·Aron Marchler-BauerStephen H Bryant
Feb 9, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Esther Aguilar-BarajasCarlos Cervantes
Apr 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Manuel Tejada-JiménezEmilio Fernández
May 14, 2011·The Journal of Biological Chemistry·Yan Zhang, Vadim N Gladyshev
May 25, 2011·Coordination Chemistry Reviews·Partha Basu, Sharon J N Burgmayer
Feb 24, 2012·Systematic Biology·Fredrik RonquistJohn P Huelsenbeck
Mar 1, 2012·Biochimica Et Biophysica Acta·Ralf R Mendel, Tobias Kruse
Mar 28, 2012·Coordination Chemistry Reviews·Yan ZhangVadim N Gladyshev
Nov 20, 2012·Genome Biology and Evolution·Yuri I Wolf, Eugene V Koonin
Dec 4, 2012·Biochimica Et Biophysica Acta·Chantal Iobbi-Nivol, Silke Leimkühler
Jun 27, 2013·Metallomics : Integrated Biometal Science·Manuel Tejada-JiménezÁngel Llamas
Sep 27, 2013·Metallomics : Integrated Biometal Science·M Jake PushieGraham N George
Oct 30, 2013·Nucleic Acids Research·Victor M MarkowitzNikos C Kyrpides
Jan 29, 2014·Chemical Reviews·Russ HillePartha Basu
Jul 2, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Ralf R Mendel, Silke Leimkühler
Nov 27, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Gudrun OttBernd Clement
Dec 11, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Yilin Hu, Markus W Ribbe
Dec 17, 2014·Biochimica Et Biophysica Acta·Tobias HartmannSilke Leimkühler
Dec 18, 2015·Nucleic Acids Research·Robert D FinnAlex Bateman
Mar 24, 2016·Molecular Biology and Evolution·Sudhir KumarKoichiro Tamura
Aug 31, 2016·Nature Microbiology·Laura A HugJillian F Banfield
Dec 8, 2016·Structure·Shuguang YuanHorst Vogel

❮ Previous
Next ❯

Citations

Oct 17, 2018·Molecular Microbiology·Lisa DemtröderBernd Masepohl
Sep 14, 2019·Metallomics : Integrated Biometal Science·Arkadiusz ZupokSilke Leimkühler
Jul 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yan Zhang, Junge Zheng
Apr 26, 2019·Metallomics : Integrated Biometal Science·Yan ZhangYinzhen Xu
Dec 5, 2020·Environmental Science and Pollution Research International·Elva CecconiMauro Tretiach
Feb 26, 2021·Genomics, Proteomics & Bioinformatics·Yinzhen XuYan Zhang

❮ Previous
Next ❯

Software Mentioned

Inkscape
TBLASTN
Interactive Tree Of Life ( iTOL ) tree of life
MrBayes
CLUSTALW
MEGA ( Molecular Evolutionary Genetics Analysis )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.