Comparative genomics of three Methanocellales strains reveal novel taxonomic and metabolic features

Environmental Microbiology Reports
Zhe Lyu, Yahai Lu

Abstract

Methanocellales represents a new order of methanogens, which is widespread in environments and plays specifically the important role in methane emissions from paddy fields. To gain more insights into Methanocellales, comparative genomic studies were performed among three Methanocellales strains through the same annotation pipeline. Genetic relationships among strains revealed by genome alignment, pan-genome reconstruction and comparison of amino average identity suggest that they should be classified in different genera. In addition, multiple copies of cell cycle regulator proteins were identified for the first time in Archaea. Core metabolisms were reconstructed, predicting certain unique and novel features for Methanocellales, including a set of methanogenesis genes potentially organized toward specialization in utilizing low concentrations of H2, a new route of disulfide reduction catalysed by a disulfide-reducing hydrogenase (Drh) complex phylogenetically related to sulfate-reducing prokaryotes, an oxidative tricarboxylic acid (TCA) cycle, a sophisticated nitrogen uptake and regulation system as well as a versatile sulfur utilization system. These core metabolisms are largely conserved among the three strains, but differenc...Continue Reading

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Citations

Aug 23, 2017·BMC Genomics·Sean P GilmoreMichelle A O'Malley
Jun 7, 2018·FEMS Microbiology Ecology·Michiel H In 't ZandtMike Sm Jetten
Oct 7, 2018·Applied and Environmental Microbiology·Simon Guerrero-CruzAnnika Vaksmaa
Dec 18, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jose Antonio MagdalenaCristina González-Fernández

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