Comparative genomics reveals selective distribution and domain organization of FYVE and PX domain proteins across eukaryotic lineages.

BMC Genomics
Sumana BanerjeeSrimonti Sarkar

Abstract

Phosphatidylinositol 3-phosphate is involved in regulation of several key cellular processes, mainly endocytosis, signaling, nuclear processes, cytoskeletal remodelling, cell survival, membrane trafficking, phagosome maturation and autophagy. In most cases effector proteins bind to this lipid, using either FYVE or PX domain. These two domains are distributed amongst varied life forms such as virus, protists, fungi, viridiplantae and metazoa. As the binding ligand is identical for both domains, the goal of this study was to understand if there is any selectivity for either of these domains in different taxa. Further, to understand the different cellular functions that these domains may be involved in, we analyzed the taxonomic distribution of additional domains that associate with FYVE and PX. There is selectivity for either FYVE or PX in individual genomes where both domains are present. Fungi and metazoa encode more PX, whereas streptophytes in viridiplantae encode more FYVE. Excess of FYVE in streptophytes results from proteins containing RCC1and DZC domains and FYVE domains in these proteins have a non-canonical ligand-binding site. Within a taxonomic group the selected domain associates with a higher number of other domains...Continue Reading

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Citations

Apr 20, 2011·Journal of Cell Science·V Lila KoumandouMark C Field
Jan 30, 2015·Frontiers in Plant Science·Anne-Sophie LeprinceArnould Savouré
Apr 28, 2021·Parasitology International·Natsuki WatanabeTomoyoshi Nozaki
Aug 6, 2021·Expert Review of Proteomics·Michael Overduin, Troy A Kervin
Aug 10, 2021·Frontiers in Cell and Developmental Biology·Troy A KervinMichael Overduin

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Software Mentioned

HMMER
Protpars
PHYLIP
ClustalW
CD
FYVE
HIT

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